VEXAS: A review of current understandings and emerging treatment strategies

VEXAS: A review of current understandings and emerging treatment strategies

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a late-onset autoinflammatory disorder, typically affecting males, caused by somatic mutations in the X-linked gene UBA1 encoding the E1 ubiquitin-activating enzyme. These mutations result in defective ubiquitination and dy...

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Bibliographic Details
Main Authors: Robert Holden, Yogeshraj Jeelal, Andrew McLean-Tooke, Kylan Pathmanathan, David Nolan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
VEXAS syndrome
VEXAS
autoinflamatory diseases
myeloid cells
myelodyslastic syndromes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1644404/full
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