Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors
PurposeThis study compared the diagnostic performance, semi-quantitative capability, and staging accuracy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT in detecting lymph node metastases.MethodsThis single-center retrospective study included 41 patients with suspected lymph node metastases who receiv...
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Frontiers Media S.A.
2025-07-01
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| Sraith: | Frontiers in Oncology |
| Ábhair: | |
| Rochtain ar líne: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1605568/full |
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| _version_ | 1839618400779763712 |
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| author | Wanjing Zhou Jiashun Dai Kai Zheng Xiang Peng Yanyin Zhang Chengzhi Jiang Jian Yang Hui Ye |
| author_facet | Wanjing Zhou Jiashun Dai Kai Zheng Xiang Peng Yanyin Zhang Chengzhi Jiang Jian Yang Hui Ye |
| author_sort | Wanjing Zhou |
| collection | DOAJ |
| description | PurposeThis study compared the diagnostic performance, semi-quantitative capability, and staging accuracy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT in detecting lymph node metastases.MethodsThis single-center retrospective study included 41 patients with suspected lymph node metastases who received both [18F]FDG and [18F]AlF-NOTA-FAPI-04 PET/CT. The study compared metastatic lymph node detection, semi-quantitative values, and N staging accuracy. Subgroup analyses were performed for lymph nodes with short-axis diameters (SADs) ≥10 and <10 mm.ResultsA total of 41 patients with 126 nodes were included. [18F]AlF-NOTA-FAPI-04 outperformed [18F]FDG in the detection of metastatic lymph nodes, achieving higher accuracy in both patient-based (92.7% vs. 70.7%, p = 0.004) and node-based analyses (91.3% vs. 60.3%, p < 0.001). In semi-quantitative analysis, the maximum standardized uptake value and target-to-background ratio of [18F]AlF-NOTA-FAPI-04 were higher than those of [18F]FDG in metastatic lymph nodes (all p < 0.001). Both tracers distinguished metastatic from benign nodes with SAD ≥ 10 mm (p < 0.05). [18F]AlF-NOTA-FAPI-04 PET/CT could distinguish between benign and metastatic lymph nodes with SAD < 10 mm (p < 0.001), whereas [18F]FDG PET/CT could not (p > 0.05). [18F]AlF-NOTA-FAPI-04 also provided more accurate N staging assessments (87.8% vs. 65.9%, p = 0.006). [18F]AlF-NOTA-FAPI-04 PET/CT enabled the correct diagnosis of more lymph nodes, leading to a change in the therapeutic regimen for eight patients (19.5%).Conclusion[18F]AlF-NOTA-FAPI-04 PET/CT demonstrated superior diagnostic performance, semi-quantitative capability, and N staging accuracy compared to [18F]FDG PET/CT, particularly for small metastatic lymph nodes (SAD < 10 mm), offering enhanced guidance for tumor staging. |
| format | Article |
| id | doaj-art-a4a533a06b3e498e9c2c93afa87f3b2a |
| institution | Matheson Library |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-a4a533a06b3e498e9c2c93afa87f3b2a2025-07-24T04:10:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16055681605568Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumorsWanjing ZhouJiashun DaiKai ZhengXiang PengYanyin ZhangChengzhi JiangJian YangHui YePurposeThis study compared the diagnostic performance, semi-quantitative capability, and staging accuracy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT in detecting lymph node metastases.MethodsThis single-center retrospective study included 41 patients with suspected lymph node metastases who received both [18F]FDG and [18F]AlF-NOTA-FAPI-04 PET/CT. The study compared metastatic lymph node detection, semi-quantitative values, and N staging accuracy. Subgroup analyses were performed for lymph nodes with short-axis diameters (SADs) ≥10 and <10 mm.ResultsA total of 41 patients with 126 nodes were included. [18F]AlF-NOTA-FAPI-04 outperformed [18F]FDG in the detection of metastatic lymph nodes, achieving higher accuracy in both patient-based (92.7% vs. 70.7%, p = 0.004) and node-based analyses (91.3% vs. 60.3%, p < 0.001). In semi-quantitative analysis, the maximum standardized uptake value and target-to-background ratio of [18F]AlF-NOTA-FAPI-04 were higher than those of [18F]FDG in metastatic lymph nodes (all p < 0.001). Both tracers distinguished metastatic from benign nodes with SAD ≥ 10 mm (p < 0.05). [18F]AlF-NOTA-FAPI-04 PET/CT could distinguish between benign and metastatic lymph nodes with SAD < 10 mm (p < 0.001), whereas [18F]FDG PET/CT could not (p > 0.05). [18F]AlF-NOTA-FAPI-04 also provided more accurate N staging assessments (87.8% vs. 65.9%, p = 0.006). [18F]AlF-NOTA-FAPI-04 PET/CT enabled the correct diagnosis of more lymph nodes, leading to a change in the therapeutic regimen for eight patients (19.5%).Conclusion[18F]AlF-NOTA-FAPI-04 PET/CT demonstrated superior diagnostic performance, semi-quantitative capability, and N staging accuracy compared to [18F]FDG PET/CT, particularly for small metastatic lymph nodes (SAD < 10 mm), offering enhanced guidance for tumor staging.https://www.frontiersin.org/articles/10.3389/fonc.2025.1605568/full[18F]AlF-NOTA-FAPI-04[18F]FDGPET/CTfibroblast activation protein (FAP)lymph node metastases |
| spellingShingle | Wanjing Zhou Jiashun Dai Kai Zheng Xiang Peng Yanyin Zhang Chengzhi Jiang Jian Yang Hui Ye Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors Frontiers in Oncology [18F]AlF-NOTA-FAPI-04 [18F]FDG PET/CT fibroblast activation protein (FAP) lymph node metastases |
| title | Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors |
| title_full | Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors |
| title_fullStr | Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors |
| title_full_unstemmed | Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors |
| title_short | Comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and [18F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors |
| title_sort | comparison of 18f alf nota fapi 04 pet ct and 18f fdg pet ct for diagnosing lymph node metastasis in malignant tumors |
| topic | [18F]AlF-NOTA-FAPI-04 [18F]FDG PET/CT fibroblast activation protein (FAP) lymph node metastases |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1605568/full |
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