Single-Nucleus Chromatin Accessibility and Epigenetic Study Uncover Cell States and Transcriptional Regulation of Epidermis in Hidradenitis Suppurativa

Single-Nucleus Chromatin Accessibility and Epigenetic Study Uncover Cell States and Transcriptional Regulation of Epidermis in Hidradenitis Suppurativa

<b>Background/Objectives:</b> Hidradenitis suppurativa (HS) is a complicated chronic inflammatory skin disorder characterized by recurrent and painful deep-seated nodules, abscesses, fistulae, scarring, and sinus tracts. HS most commonly affects high-density hair follicles and apocrine g...

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Bibliographic Details
Main Authors: Safiya Haque, Suha Mohiuddin, Jasim Khan, Suhail Muzaffar, Sudeepthi Vejendla, Yanfeng Zhang, Masakazu Kamata, Lin Jin
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
hidradenitis suppurativa
epigenetic regulation
single-nucleus chromatin accessibility
ATF3
Online Access:https://www.mdpi.com/2227-9059/13/7/1599
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