Effects of a 24-week yoga intervention on choriocapillaris density in Parkinson’s disease
Introduction: Parkinson’s disease (PD) involves systemic microvascular dysfunction, with choriocapillaris density (CCD) potentially reflecting it. This study examined whether a 24-week yoga intervention alters CCD in PD and whether responses differ by disease duration, severity, or intervention styl...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Clinical Parkinsonism & Related Disorders |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590112525000647 |
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| Summary: | Introduction: Parkinson’s disease (PD) involves systemic microvascular dysfunction, with choriocapillaris density (CCD) potentially reflecting it. This study examined whether a 24-week yoga intervention alters CCD in PD and whether responses differ by disease duration, severity, or intervention style. Methods: Fifteen PD patients completed a supervised 24-week yoga program involving two Hatha-based styles. CCD was measured using 3 × 3 mm macular optical coherence tomography angiography (OCTA) centered on 2.5-mm foveal region. Clinical assessments included disease duration, Hoehn and Yahr (H&Y) stage, and Montreal Cognitive Assessment (MoCA), conducted at baseline and after intervention. Correlation, stratified, and subgroup analyses were performed. Results: No significant change in CCD was observed at the group level (62.9 % ± 3.9 % vs. 62.9 % ± 3.2 %; P > 0.05). Baseline CCD was inversely correlated with disease duration and H&Y stage (ρ = −0.71, P = 0.003). Patients with shorter disease duration (<5 years) or early-stage PD (H&Y stage 1) showed significant CCD reductions (ΔCCD = −4.7 %, P = 0.003; ΔCCD = −4.3 %, P = 0.002), whereas those with longer duration or advanced stage (H&Y 2–3) exhibited mild increases (ΔCCD = +2.3 %, ΔCCD = +2.8 %). Baseline CCD was inversely correlated with ΔCCD (ρ = −0.77, P < 0.001). CCD did not differ between the YogaCue and Hatha Yoga groups at baseline, follow-up, or in ΔCCD (P > 0.05). Conclusions: These findings provide preliminary evidence that CCD responses to yoga vary with disease stage but not intervention style, suggesting a potential role for CCD as a vascular marker to inform individualized rehabilitation in PD. |
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| ISSN: | 2590-1125 |