MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE
The paper considers the requirements to the production of pharmaceutical substances and the current trends in the toxicity assessment of the preparations obtained. The results of research of the use cell cultures for test bioactive substances, including cholera toxin are given. Evaluated are the adv...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/558 |
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| _version_ | 1839586802924519424 |
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| author | A. V. Gaeva O. V. Gromova O. S. Durakov S. V. Generalov O. A. Volokh |
| author_facet | A. V. Gaeva O. V. Gromova O. S. Durakov S. V. Generalov O. A. Volokh |
| author_sort | A. V. Gaeva |
| collection | DOAJ |
| description | The paper considers the requirements to the production of pharmaceutical substances and the current trends in the toxicity assessment of the preparations obtained. The results of research of the use cell cultures for test bioactive substances, including cholera toxin are given. Evaluated are the advantages of in vitro methods application, in particular, continuous cell lines at some stages of cholera chemical vaccine manufacturing. |
| format | Article |
| id | doaj-art-a44bf35b10ac45e88ec31fbd1740a2f7 |
| institution | Matheson Library |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-a44bf35b10ac45e88ec31fbd1740a2f72025-08-03T19:23:53ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101152157558MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINEA. V. Gaeva0O. V. Gromova1O. S. Durakov2S. V. Generalov3O. A. Volokh4Russian Research Anti-Plague Institute «Microbe» of the RospotrebnadzorRussian Research Anti-Plague Institute «Microbe» of the RospotrebnadzorRussian Research Anti-Plague Institute «Microbe» of the RospotrebnadzorRussian Research Anti-Plague Institute «Microbe» of the RospotrebnadzorRussian Research Anti-Plague Institute «Microbe» of the RospotrebnadzorThe paper considers the requirements to the production of pharmaceutical substances and the current trends in the toxicity assessment of the preparations obtained. The results of research of the use cell cultures for test bioactive substances, including cholera toxin are given. Evaluated are the advantages of in vitro methods application, in particular, continuous cell lines at some stages of cholera chemical vaccine manufacturing.https://www.pharmjournal.ru/jour/article/view/558vaccinestoxigenicitycell culture |
| spellingShingle | A. V. Gaeva O. V. Gromova O. S. Durakov S. V. Generalov O. A. Volokh MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE Разработка и регистрация лекарственных средств vaccines toxigenicity cell culture |
| title | MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE |
| title_full | MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE |
| title_fullStr | MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE |
| title_full_unstemmed | MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE |
| title_short | MODERN APPROACHES TO THE CONTROL OF ACTIVE COMPONENTS OF CHOLERA CHEMICAL VACCINE |
| title_sort | modern approaches to the control of active components of cholera chemical vaccine |
| topic | vaccines toxigenicity cell culture |
| url | https://www.pharmjournal.ru/jour/article/view/558 |
| work_keys_str_mv | AT avgaeva modernapproachestothecontrolofactivecomponentsofcholerachemicalvaccine AT ovgromova modernapproachestothecontrolofactivecomponentsofcholerachemicalvaccine AT osdurakov modernapproachestothecontrolofactivecomponentsofcholerachemicalvaccine AT svgeneralov modernapproachestothecontrolofactivecomponentsofcholerachemicalvaccine AT oavolokh modernapproachestothecontrolofactivecomponentsofcholerachemicalvaccine |