Precise Editing of chNHE1 Gene via CRISPR/Cas9 Generates ALV-J-Resistant Chicken Primordial Germ Cell

Precise Editing of chNHE1 Gene via CRISPR/Cas9 Generates ALV-J-Resistant Chicken Primordial Germ Cell

Avian leukosis virus subgroup J (ALV-J), an α-retrovirus, mediates infection by binding to the host-specific receptor chNHE1 (chicken sodium–hydrogen exchanger type 1), leading to immunosuppression and tumorigenesis, which severely threatens the sustainable development of the poultry industry. Studi...

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Bibliographic Details
Main Authors: Xinyi Zhou, Ruyu Liao, Min Tan, Yu Zhang, Haiwei Wang, Keshan Zhang, Qigui Wang, Xi Lan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Animals
Subjects:
gene editing
CRISPR/Cas9
avian leukosis virus subgroup J (ALV-J)
chNHE1
primordial germ cells (PGCs)
Online Access:https://www.mdpi.com/2076-2615/15/14/2018
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