Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity
The genus <i>Datura</i> L. has pharmacological activities due to its source of bioactive compounds. The effects of bioactive compounds can vary depending on species, geographical location, and environmental conditions. The purpose of this review is to summarize the most recent progress a...
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2025-07-01
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| author | Khoirunnisa Assidqi Nesti Fronika Sianipar Dave Mangindaan Chukwunwike Uchenna Enyi |
| author_facet | Khoirunnisa Assidqi Nesti Fronika Sianipar Dave Mangindaan Chukwunwike Uchenna Enyi |
| author_sort | Khoirunnisa Assidqi |
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| description | The genus <i>Datura</i> L. has pharmacological activities due to its source of bioactive compounds. The effects of bioactive compounds can vary depending on species, geographical location, and environmental conditions. The purpose of this review is to summarize the most recent progress and to provide a comprehensive overview of studies concerning genetic alteration and bioactive compounds in the genus <i>Datura</i>, based on Scopus publications between 2015 and 2025. Throughout history, the genus <i>Datura</i> (Solanaceae) contains nine species of medicinal plants. A key component of elucidating the diversification process of congeneric species is identifying the factors that encourage species variation. A comparative gene family analysis provides an understanding of the evolutionary history of species by identifying common genetic/genomic mechanisms that are responsible for species responses to biotic and abiotic environments. The diverse range of bioactive compounds it contains contributes to its unique bioactivity. <i>Datura</i> contains tropane alkaloids (such as hyoscyamine and scopolamine), datumetine, withametelin, daturaolone, and atropine. Several compounds have been isolated and refined for use in treating various conditions as a result of recent progress in therapeutic development. Daturaolone, for example, is used to treat certain neurological disorders. In addition to providing renewed opportunities for the discovery of new compounds, these advancements also provide insights into the genetic basis for their biosynthesis. Our discussion also includes pitfalls as well as relevant publications regarding natural products and their pharmacological properties. The pace of discovery of bioactive compounds is set to accelerate dramatically shortly, owing to both careful perspectives and new developments. |
| format | Article |
| id | doaj-art-a3f00d35fa604fdf9cb40b950de5cf49 |
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| publishDate | 2025-07-01 |
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| spelling | doaj-art-a3f00d35fa604fdf9cb40b950de5cf492025-07-25T13:34:38ZengMDPI AGPlants2223-77472025-07-011414224410.3390/plants14142244Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological ActivityKhoirunnisa Assidqi0Nesti Fronika Sianipar1Dave Mangindaan2Chukwunwike Uchenna Enyi3Biotechnology Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, IndonesiaBiotechnology Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, IndonesiaWaste-Food-Environmental Nexus Research Interest Group, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, IndonesiaDepartment of Food Science and Technology, University of Agriculture and Environmental Science, Umuagwo, P.M.B., Owerri 1038, Imo, NigeriaThe genus <i>Datura</i> L. has pharmacological activities due to its source of bioactive compounds. The effects of bioactive compounds can vary depending on species, geographical location, and environmental conditions. The purpose of this review is to summarize the most recent progress and to provide a comprehensive overview of studies concerning genetic alteration and bioactive compounds in the genus <i>Datura</i>, based on Scopus publications between 2015 and 2025. Throughout history, the genus <i>Datura</i> (Solanaceae) contains nine species of medicinal plants. A key component of elucidating the diversification process of congeneric species is identifying the factors that encourage species variation. A comparative gene family analysis provides an understanding of the evolutionary history of species by identifying common genetic/genomic mechanisms that are responsible for species responses to biotic and abiotic environments. The diverse range of bioactive compounds it contains contributes to its unique bioactivity. <i>Datura</i> contains tropane alkaloids (such as hyoscyamine and scopolamine), datumetine, withametelin, daturaolone, and atropine. Several compounds have been isolated and refined for use in treating various conditions as a result of recent progress in therapeutic development. Daturaolone, for example, is used to treat certain neurological disorders. In addition to providing renewed opportunities for the discovery of new compounds, these advancements also provide insights into the genetic basis for their biosynthesis. Our discussion also includes pitfalls as well as relevant publications regarding natural products and their pharmacological properties. The pace of discovery of bioactive compounds is set to accelerate dramatically shortly, owing to both careful perspectives and new developments.https://www.mdpi.com/2223-7747/14/14/2244pharmacological activitybioactive compoundmorphologicalmolecularenvironmental conditionsgenus <i>Datura</i> |
| spellingShingle | Khoirunnisa Assidqi Nesti Fronika Sianipar Dave Mangindaan Chukwunwike Uchenna Enyi Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity Plants pharmacological activity bioactive compound morphological molecular environmental conditions genus <i>Datura</i> |
| title | Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity |
| title_full | Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity |
| title_fullStr | Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity |
| title_full_unstemmed | Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity |
| title_short | Genus Datura: An Exploration of Genetic Alterations, Bioactive Compounds, and Pharmacological Activity |
| title_sort | genus datura an exploration of genetic alterations bioactive compounds and pharmacological activity |
| topic | pharmacological activity bioactive compound morphological molecular environmental conditions genus <i>Datura</i> |
| url | https://www.mdpi.com/2223-7747/14/14/2244 |
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