Association of СОМТ gene polymorphisms with Parkinson’s disease
Parkinson’s disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamin...
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Siberian State Medical University (Tomsk)
2017-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/957 |
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| author | Svetlana A. Ivanova Valentina M. Alifirova Irina A. Zhukova Vladimir V. Tiguntsev Ivan V. Pozhidaev Diana Z. Osmanova Olga Yu. Fedorenko Maxim B. Freydin Yulia S. Mironova Natalia G. Zhukova Nikolay A. Bokhan Anton J.M. Loonen |
| author_facet | Svetlana A. Ivanova Valentina M. Alifirova Irina A. Zhukova Vladimir V. Tiguntsev Ivan V. Pozhidaev Diana Z. Osmanova Olga Yu. Fedorenko Maxim B. Freydin Yulia S. Mironova Natalia G. Zhukova Nikolay A. Bokhan Anton J.M. Loonen |
| author_sort | Svetlana A. Ivanova |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson’s disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson’s disease. |
| format | Article |
| id | doaj-art-a3d567e06fbd46ed91b7ceb3a80df791 |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-a3d567e06fbd46ed91b7ceb3a80df7912025-08-04T16:45:40ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-10-01163707810.20538/1682-0363-2017-3-70-78709Association of СОМТ gene polymorphisms with Parkinson’s diseaseSvetlana A. Ivanova0Valentina M. Alifirova1Irina A. Zhukova2Vladimir V. Tiguntsev3Ivan V. Pozhidaev4Diana Z. Osmanova5Olga Yu. Fedorenko6Maxim B. Freydin7Yulia S. Mironova8Natalia G. Zhukova9Nikolay A. Bokhan10Anton J.M. Loonen11Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS); National Research Tomsk Polytechnic University (NR TPU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS)Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS); National Research Tomsk State University (NR TSU)Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS); National Research Tomsk State University (NR TSU)Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS); National Research Tomsk Polytechnic University (NR TPU)Research Institute of Medical Genetics, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS); Siberian State Medical University (SSMU); National Research Tomsk State University (NR TSU)Groningen Research Institute of Pharmacy (GRIP), University of GroningenParkinson’s disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson’s disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson’s disease.https://bulletin.ssmu.ru/jour/article/view/957parkinson’s diseasesingle nucleotide polymorphismscomt gene |
| spellingShingle | Svetlana A. Ivanova Valentina M. Alifirova Irina A. Zhukova Vladimir V. Tiguntsev Ivan V. Pozhidaev Diana Z. Osmanova Olga Yu. Fedorenko Maxim B. Freydin Yulia S. Mironova Natalia G. Zhukova Nikolay A. Bokhan Anton J.M. Loonen Association of СОМТ gene polymorphisms with Parkinson’s disease Бюллетень сибирской медицины parkinson’s disease single nucleotide polymorphisms comt gene |
| title | Association of СОМТ gene polymorphisms with Parkinson’s disease |
| title_full | Association of СОМТ gene polymorphisms with Parkinson’s disease |
| title_fullStr | Association of СОМТ gene polymorphisms with Parkinson’s disease |
| title_full_unstemmed | Association of СОМТ gene polymorphisms with Parkinson’s disease |
| title_short | Association of СОМТ gene polymorphisms with Parkinson’s disease |
| title_sort | association of сомт gene polymorphisms with parkinson s disease |
| topic | parkinson’s disease single nucleotide polymorphisms comt gene |
| url | https://bulletin.ssmu.ru/jour/article/view/957 |
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