Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock
The objective of this study was to perform genome-wide association analysis and thus search for candidate genes for milk production and composition, milk coagulation properties (MCP), and milk protein profile in dairy sheep from a New Zealand flock. After quality control, 45,801 single nucleotide po...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Animal Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2025.2516688 |
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| author | A. C. Marshall N. Lopez-Villalobos V. Vigolo M. De Marchi S. M. Loveday M. Weeks W. McNabb |
| author_facet | A. C. Marshall N. Lopez-Villalobos V. Vigolo M. De Marchi S. M. Loveday M. Weeks W. McNabb |
| author_sort | A. C. Marshall |
| collection | DOAJ |
| description | The objective of this study was to perform genome-wide association analysis and thus search for candidate genes for milk production and composition, milk coagulation properties (MCP), and milk protein profile in dairy sheep from a New Zealand flock. After quality control, 45,801 single nucleotide polymorphisms (SNPs) were included in the analysis, 147 ewes, and 470 individual records. A total of 87 SNPs and 55 candidate genes were found across Ovis aries autosomes (OAR) 2, 3, 6, 16, 18, 20, 25, and 26. Of particular importance, were the candidate genes PDZRN4 for milk yield, and BMP2K for contents of αs1- and αs2-caseins. No SNPs were found in the casein genes, LALBA or PAEP. Only one SNP was significant for MCP, and overall, the genetic architecture of MCP was similar to that of ratio of casein to calcium, pH, lactose, and the ratio of casein to protein. Further studies with larger flocks and with genomic imputation are required to validate the findings of this study before incorporating markers or genes into breeding programmes. |
| format | Article |
| id | doaj-art-a3be9bbbb7174fa482a0acd8f1c24e69 |
| institution | Matheson Library |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-a3be9bbbb7174fa482a0acd8f1c24e692025-07-11T15:53:44ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782025-12-0136110.1080/10495398.2025.2516688Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flockA. C. Marshall0N. Lopez-Villalobos1V. Vigolo2M. De Marchi3S. M. Loveday4M. Weeks5W. McNabb6School of Agriculture and Environment, Massey University, Palmerston North, New ZealandSchool of Agriculture and Environment, Massey University, Palmerston North, New ZealandDepartment of Agronomy, Food, Natural resources, Animals and Environment, University of Padova, Legnaro, ItalyDepartment of Agronomy, Food, Natural resources, Animals and Environment, University of Padova, Legnaro, ItalyThe Riddet Institute, Massey University, Palmerston North, New ZealandAgResearch Ltd, Smart Foods & Bioproducts Group, Te Ohu Rangahau Kai, Massey University, Palmerston North, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandThe objective of this study was to perform genome-wide association analysis and thus search for candidate genes for milk production and composition, milk coagulation properties (MCP), and milk protein profile in dairy sheep from a New Zealand flock. After quality control, 45,801 single nucleotide polymorphisms (SNPs) were included in the analysis, 147 ewes, and 470 individual records. A total of 87 SNPs and 55 candidate genes were found across Ovis aries autosomes (OAR) 2, 3, 6, 16, 18, 20, 25, and 26. Of particular importance, were the candidate genes PDZRN4 for milk yield, and BMP2K for contents of αs1- and αs2-caseins. No SNPs were found in the casein genes, LALBA or PAEP. Only one SNP was significant for MCP, and overall, the genetic architecture of MCP was similar to that of ratio of casein to calcium, pH, lactose, and the ratio of casein to protein. Further studies with larger flocks and with genomic imputation are required to validate the findings of this study before incorporating markers or genes into breeding programmes.https://www.tandfonline.com/doi/10.1080/10495398.2025.2516688Sheep milkdairy sheepmilk productionmilk compositionprotein profilegenome-wide association |
| spellingShingle | A. C. Marshall N. Lopez-Villalobos V. Vigolo M. De Marchi S. M. Loveday M. Weeks W. McNabb Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock Animal Biotechnology Sheep milk dairy sheep milk production milk composition protein profile genome-wide association |
| title | Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock |
| title_full | Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock |
| title_fullStr | Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock |
| title_full_unstemmed | Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock |
| title_short | Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock |
| title_sort | candidate gene search for milk production and composition milk coagulation properties and milk protein profile in dairy sheep from a new zealand flock |
| topic | Sheep milk dairy sheep milk production milk composition protein profile genome-wide association |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2025.2516688 |
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