Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery

QR Code

Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery

5–10 % of breast cancer cases are hereditary, 30 % of them are caused by BRCA1 and BRCA2 mutations (breast / ovarian cancer syndrome). Average cumulative risks of breast and ovarian cancer in BRCA1 mutation carriers run up to 87 % and 44 %, correspondingly. The risk for contralateral breast cancer i...

Full description

Saved in:

Bibliographic Details
Main Authors:	L. N. Lyubchenko, Ye. I. Bateneva, I. K. Vorotnikov, S. M. Portnoy, O. V. Krokhina, V. A. Sobolevskiy, L. G. Zhukova, V. A. Khaylenko, S. A. Tyulyandin
Format:	Article
Language:	Russian
Published:	ABV-press 2015-06-01
Series:	Успехи молекулярной онкологии
Subjects:	hereditary breast cancer hereditary ovarian cancer brca1 brca2 mutation single nucleotide polymorphism genetic counselling genetic testing prophylactic mastectomy prophylactic oophorectomy
Online Access:	https://umo.abvpress.ru/jour/article/view/20
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

MEDICAL AND GENETIC COUNSELING OF HEREDITARY BREAST AND OVARIAN CANCER
by: S. A. Laptiev, et al.
Published: (2018-06-01)

Prophylactic adnexectomy in BRCA1 and BRCA2 gene mutation carriers (а review of literature)
by: T. A. Shendrikova, et al.
Published: (2014-07-01)

Hereditary diffuse gastric cancer syndrome: medical genetic consulting, treatment strategy for family members, prophylactic total gastrectomy, and endoscopic surveillance in CDH1- and CTNNA1-mutation carriers
by: N. V. Kovalenko, et al.
Published: (2022-06-01)

REPARATION SYSTEM GENES: POPULATION DIFFERENCES IN HEREDITARY OVARIAN AND BREAST CANCER DETERMINED BY NEXT-GENERATION SEQUENCING
by: O. I. Brovkina, et al.
Published: (2017-06-01)

HEREDITARY MULTIPLE PRIMARY BREAST AND OVARIAN CANCER (CASE REPORT)
by: Е. V. Panferova, et al.
Published: (2016-02-01)

BRCA1, BRCA2 mutations — future of predictive oncology: a review of literature
by: V. N. Dmitriev, et al.
Published: (2014-07-01)

CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER
by: K. B. Kotiv, et al.
Published: (2017-12-01)

HEREDITARY CHARACTERISTICS BRCA1 5382INSC/СHEK2/BLM-ASSOCIATED BREAST CANCER
by: Е. М. Bit-Sava
Published: (2016-02-01)

HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY
by: L. N. Lyubchenko, et al.
Published: (2018-09-01)

Genetic counseling for hereditary cancer syndromes: a 5-year experience from a single center in Bulgaria
by: Mari Hachmeriyan, et al.
Published: (2025-07-01)

Factors influencing decision-making on opportunistic salpingo-oophorectomy for ovarian cancer prevention in women with gastrointestinal cancers undergoing intra-abdominal surgery
by: Jaekyung Bae, et al.
Published: (2025-08-01)

Genetic heterogeneity of hereditary diseases of nervous system: problems and solutions
by: E. L. Dadali, et al.
Published: (2015-02-01)

A RARE CASE OF MULTIPLE-PRIMARY CANCER IN A WOMAN WITH BRCA 1 GENE MUTATION: BRCA-ASSOCIATED OVARIAN CANCER AND LUNG CARCINOID TUMOR
by: A. О. Ivantsov, et al.
Published: (2018-03-01)

High rate of mutations in the BRCA1, BRCA2, CHEK2, NBN, and BLM genes in Russian ovarian cancer patients
by: Ye. I. Bateneva, et al.
Published: (2015-01-01)

Breast magnetic resonance imaging significance for breast cancer diagnostic in women with genetic predisposition and a strong family history
by: M. S. Karpova, et al.
Published: (2014-07-01)

Four magnetic resonance imaging surveillance-detected breast cancer cases in cancer-free BRCA1/2 mutation carriers
by: Megumi Takaoka, et al.
Published: (2021-10-01)

Genotype-phenotype correlations in patients with breast cancer and BRCA1 mutations (4153delA, 185delAG, 5382insC)
by: Ye. M. Bit-Sava, et al.
Published: (2014-07-01)

Generating a database by calculating the pathogenic variants and allele frequencies detected in hereditary cancers using genomic data: A nation study
by: Manal Salah Babiker Ali, et al.
Published: (2025-09-01)

Challenges in prenatal diagnosis and genetic counselling in compound heterozygosity for beta thalassemia and hereditary persistence of fetal hemoglobin (HPFH)
by: Dolat Singh Shekhawat, et al.
Published: (2025-06-01)

DETECTION OF MUTATIONS RELATED TO HEREDITARY CANCER IN RELATIVES OF BREAST CANCER PATIENTS
by: G. A. Paul, et al.
Published: (2017-09-01)

Clinical and genetic characteristics and diagnosis of hereditary variants of neonatal epilepsy
by: N. A. Semenova, et al.
Published: (2017-11-01)

Role of BRCA 1 и BRCA 2 gene mutations in the occurrence of male breast cancer
by: A. V. Bykova, et al.
Published: (2014-07-01)

Ethnic aspects of hereditary breast cancer
by: P. A. Gervas, et al.
Published: (2019-04-01)

The spectrum of BRCA1 gene mutations in early onset breast cancer patients from Russia
by: M. S. Anisimenko, et al.
Published: (2018-09-01)

Control of hereditary diseases : report of a WHO Scientific Group.
Published: (1996)

Women's Intention to Participate in Predictive Breast Cancer Genetic Testing: A Cross‐Sectional Survey of in Iran
by: Zahra Meshkani, et al.
Published: (2025-07-01)

Contralateral prophylactic mastectomy rate and predictive factors among patients with breast cancer who underwent multigene panel testing for hereditary cancer
by: Nisreen Elsayegh, et al.
Published: (2018-06-01)

Ovarian cancer: new accents treatment of patients with platinum-sensitive relapses
by: A. G. Kedrova, et al.
Published: (2016-11-01)

TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER
by: A. D. Zikiryakhodzhaev, et al.
Published: (2017-06-01)

Hereditary breast cancer and ovarian cancer: clinical course and treatment
by: V. V. Semiglazov, et al.
Published: (2021-03-01)

Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
by: E. M. Kagirova, et al.
Published: (2023-11-01)

ENDOCRINE ASPECTS OF PROPHYLACTIC OF TEENAGERS OF KRASNODAR
by: S. A. Shadrin, et al.
Published: (2017-07-01)

Tactics of radiographic diagnostics of breast cancer in women with inherited predisposition
by: M. S. Karpova, et al.
Published: (2015-01-01)

EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER
by: L. N. Lyubchenko, et al.
Published: (2017-12-01)

External quality assessment of genetic testing for hereditary hearing loss in Shanghai and other regions
by: Yun Bao, et al.
Published: (2025-09-01)

Features and complexity of treatment of <i>BRCA</i>-associated ovarian cancer, chronic disease: literature review
by: T. V. Gorodnova, et al.
Published: (2024-11-01)

RISK FACTORS OF OVARIAN CANCER AND POSSIBLE PREVENTIVE STRATEGIES
by: OLGA B. Karelina, et al.
Published: (2018-09-01)

Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer
by: A. V. Semyanikhina, et al.
Published: (2019-07-01)

A Single-Center Case Series of Hereditary Ataxia from Gujarat: Clinical and Genetic Data
by: Pranav Joshi, et al.
Published: (2025-07-01)

Study of the Carrier State for Five BRCA1/BRCA2 Deleterious Mutations in Bulgarian Women with Breast Cancer
by: Katia Kovacheva, et al.
Published: (2013-12-01)