Features of Food Hypersensitivity in Children with Autism Spectrum Disorder
Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of...
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Scientific Сentre for Family Health and Human Reproduction Problems
2019-11-01
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| Loạt: | Acta Biomedica Scientifica |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.actabiomedica.ru/jour/article/view/2171 |
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| _version_ | 1839611986669731840 |
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| author | M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia |
| author_facet | M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia |
| author_sort | M. I. Khudiakova |
| collection | DOAJ |
| description | Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of food hypersensitivity, the balance of interleukins and psychophysiological parameters in children with ASD.Methods. A prospective cohort study of children aged 7 ± 2 years, healthy and diagnosed with ASD was performed. Determination of specific immunoglobulin concentrations to 111 food antigens and interleukins was measured by ELISA. Psychophysiological indicators of communicative competence in children with ASD were evaluated in the ATEC-test.Results. It was established that in children with ASD (n = 69), the frequency of occurrence of food hypersensitivity and indicators of specific sIgG concentrations to food antigens of dairy and grain products are higher (р < 0.05). A direct correlation was found between the concentration of INFγ, IgG concentrations to antigens of dairy, grain products and C. albicans. High ratios of the INFγ/IL4 and INFγ/IL10 ratios (p < 0.05) were revealed. As a result of compliance with the elimination diet was noted significant decrease in the concentration of sIgG to food antigens, sIgG to C. albicans, changes indicators following the results of ATEC testing.The data obtained revealed the unexplored effects the influence of specific food hypersensitivity on the process of initiation and maintenance of immune inflammation, as well as on the communicative competence in pathological conditions. A personalized elimination diet can improve the immunorehabilitation and the quality of life of children with autism. |
| format | Article |
| id | doaj-art-a35394941ba54d99bf2e2bc4e9f736f1 |
| institution | Matheson Library |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2019-11-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-a35394941ba54d99bf2e2bc4e9f736f12025-07-28T14:03:24ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962019-11-0145606710.29413/ABS.2019-4.5.101930Features of Food Hypersensitivity in Children with Autism Spectrum DisorderM. I. Khudiakova0N. A. Cherevko1A. V. Skirnevskaia2M. Yu. Rozenshtein3A. Z. Rozenshtein4S. E. Kondakov5K. V. Berezovskaia6Siberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityOOO ImmunoHealth RusOOO ImmunoHealth RusLomonosov Moscow State UniversityMedical Association OOO “Center of Family Medicine”Currently, the incidence of autism spectrum disorders (ASD) continues to increase in the children’s population. However, the pathogenesis of autism remains controversial.The purpose of this work is to evaluate the performance of the elimination nutritional approaches to the dynamics of indicators of food hypersensitivity, the balance of interleukins and psychophysiological parameters in children with ASD.Methods. A prospective cohort study of children aged 7 ± 2 years, healthy and diagnosed with ASD was performed. Determination of specific immunoglobulin concentrations to 111 food antigens and interleukins was measured by ELISA. Psychophysiological indicators of communicative competence in children with ASD were evaluated in the ATEC-test.Results. It was established that in children with ASD (n = 69), the frequency of occurrence of food hypersensitivity and indicators of specific sIgG concentrations to food antigens of dairy and grain products are higher (р < 0.05). A direct correlation was found between the concentration of INFγ, IgG concentrations to antigens of dairy, grain products and C. albicans. High ratios of the INFγ/IL4 and INFγ/IL10 ratios (p < 0.05) were revealed. As a result of compliance with the elimination diet was noted significant decrease in the concentration of sIgG to food antigens, sIgG to C. albicans, changes indicators following the results of ATEC testing.The data obtained revealed the unexplored effects the influence of specific food hypersensitivity on the process of initiation and maintenance of immune inflammation, as well as on the communicative competence in pathological conditions. A personalized elimination diet can improve the immunorehabilitation and the quality of life of children with autism.https://www.actabiomedica.ru/jour/article/view/2171autism spectrum disorderfood hypersensitivitypersonalized elimination dietinterleukins |
| spellingShingle | M. I. Khudiakova N. A. Cherevko A. V. Skirnevskaia M. Yu. Rozenshtein A. Z. Rozenshtein S. E. Kondakov K. V. Berezovskaia Features of Food Hypersensitivity in Children with Autism Spectrum Disorder Acta Biomedica Scientifica autism spectrum disorder food hypersensitivity personalized elimination diet interleukins |
| title | Features of Food Hypersensitivity in Children with Autism Spectrum Disorder |
| title_full | Features of Food Hypersensitivity in Children with Autism Spectrum Disorder |
| title_fullStr | Features of Food Hypersensitivity in Children with Autism Spectrum Disorder |
| title_full_unstemmed | Features of Food Hypersensitivity in Children with Autism Spectrum Disorder |
| title_short | Features of Food Hypersensitivity in Children with Autism Spectrum Disorder |
| title_sort | features of food hypersensitivity in children with autism spectrum disorder |
| topic | autism spectrum disorder food hypersensitivity personalized elimination diet interleukins |
| url | https://www.actabiomedica.ru/jour/article/view/2171 |
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