Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children
Abstract Background Raised intracranial pressure (ICP) is a typical neurological problem in critically ill children, which is associated with poor clinical outcomes or even death. The purpose of the study was to evaluate the efficacy of optic nerve sheath diameter (ONSD) as a point-of-care testing i...
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BMC
2025-06-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-025-05798-z |
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| author | Ahmed A. EL-Nawawy Ahmed A. El Beheiry Aya M. Abdelaziz Hadir M. Hassouna |
| author_facet | Ahmed A. EL-Nawawy Ahmed A. El Beheiry Aya M. Abdelaziz Hadir M. Hassouna |
| author_sort | Ahmed A. EL-Nawawy |
| collection | DOAJ |
| description | Abstract Background Raised intracranial pressure (ICP) is a typical neurological problem in critically ill children, which is associated with poor clinical outcomes or even death. The purpose of the study was to evaluate the efficacy of optic nerve sheath diameter (ONSD) as a point-of-care testing in the pediatric intensive care units for early diagnosis of raised intracranial pressure and as a follow up tool for treatment response. Method A prospective observational study was conducted in the pediatric intensive care unit of a tertiary care children's hospital. Consecutive children aged one month to twelve years with Glasgow Coma Scale less than or equal to 8 were included. Brain CT was performed just before or within few hours of admission to identify raised ICP. Two trained examiners in the same work place, who were blinded to the clinical details of the patients, performed the ONSD sonography concurrently. The ONSD was measured in the left and right eyes on admission, after 1 h, after 12 h, and after 24 h. Results Forty-two patients were categorized into 29 children with raised ICP and 13 children with non-raised ICP. The ONSD was significantly higher in the raised ICP group at all times in both eyes. It showed a significant decrease over time in both groups. A cutoff value of ≥ 4.3 mm was found to be an acceptable discriminator of ICP with Area Under the ROC curve (AUC) = 0.788 (95% CI 0.740- 0.830) (p < 0.0001), sensitivity of 59.91% (95% CI: 53.30–66.27) and specificity of 83.65% (95% CI: 75.12–90.18). Conclusions In critically ill children with non-traumatic causes of raised ICP, point of care ultrasound of ONSD shows a good diagnostic test accuracy for early diagnosis of raised ICP as well as follow up tool of treatment response if used serially. In addition, it is very good at correctly identifying individuals who do not have raised ICP to avoid unnecessary interventions. |
| format | Article |
| id | doaj-art-a304801d6f3f42a19b72db21bc3199bd |
| institution | Matheson Library |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-a304801d6f3f42a19b72db21bc3199bd2025-06-29T11:17:03ZengBMCBMC Pediatrics1471-24312025-06-012511910.1186/s12887-025-05798-zPoint of care ultrasound assessment of the optic nerve sheath diameter in critically ill childrenAhmed A. EL-Nawawy0Ahmed A. El Beheiry1Aya M. Abdelaziz2Hadir M. Hassouna3Department of Pediatrics, Faculty of Medicine, Alexandria UniversityDepartment of Radiolody, Faculty of Medicine, Alexandria UniversityDepartment of Pediatrics, Faculty of Medicine, Alexandria UniversityDepartment of Pediatrics, Faculty of Medicine, Alexandria UniversityAbstract Background Raised intracranial pressure (ICP) is a typical neurological problem in critically ill children, which is associated with poor clinical outcomes or even death. The purpose of the study was to evaluate the efficacy of optic nerve sheath diameter (ONSD) as a point-of-care testing in the pediatric intensive care units for early diagnosis of raised intracranial pressure and as a follow up tool for treatment response. Method A prospective observational study was conducted in the pediatric intensive care unit of a tertiary care children's hospital. Consecutive children aged one month to twelve years with Glasgow Coma Scale less than or equal to 8 were included. Brain CT was performed just before or within few hours of admission to identify raised ICP. Two trained examiners in the same work place, who were blinded to the clinical details of the patients, performed the ONSD sonography concurrently. The ONSD was measured in the left and right eyes on admission, after 1 h, after 12 h, and after 24 h. Results Forty-two patients were categorized into 29 children with raised ICP and 13 children with non-raised ICP. The ONSD was significantly higher in the raised ICP group at all times in both eyes. It showed a significant decrease over time in both groups. A cutoff value of ≥ 4.3 mm was found to be an acceptable discriminator of ICP with Area Under the ROC curve (AUC) = 0.788 (95% CI 0.740- 0.830) (p < 0.0001), sensitivity of 59.91% (95% CI: 53.30–66.27) and specificity of 83.65% (95% CI: 75.12–90.18). Conclusions In critically ill children with non-traumatic causes of raised ICP, point of care ultrasound of ONSD shows a good diagnostic test accuracy for early diagnosis of raised ICP as well as follow up tool of treatment response if used serially. In addition, it is very good at correctly identifying individuals who do not have raised ICP to avoid unnecessary interventions.https://doi.org/10.1186/s12887-025-05798-zCritically ill childrenIntracranial pressureIntensive care unitNon-invasive monitoringOptic nerve sheath diameterPoint-of- care ultrasound |
| spellingShingle | Ahmed A. EL-Nawawy Ahmed A. El Beheiry Aya M. Abdelaziz Hadir M. Hassouna Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children BMC Pediatrics Critically ill children Intracranial pressure Intensive care unit Non-invasive monitoring Optic nerve sheath diameter Point-of- care ultrasound |
| title | Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| title_full | Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| title_fullStr | Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| title_full_unstemmed | Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| title_short | Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| title_sort | point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children |
| topic | Critically ill children Intracranial pressure Intensive care unit Non-invasive monitoring Optic nerve sheath diameter Point-of- care ultrasound |
| url | https://doi.org/10.1186/s12887-025-05798-z |
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