Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer
Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an independent value of the level of expression of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/52 |
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| _version_ | 1839591239703330816 |
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| author | A. A. Samuseva R. V. Lyubota A. S. Zotov R. I. Vereshchako |
| author_facet | A. A. Samuseva R. V. Lyubota A. S. Zotov R. I. Vereshchako |
| author_sort | A. A. Samuseva |
| collection | DOAJ |
| description | Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an independent value of the level of expression of topoisomerase 2a in the course of chemotherapy with anthracycline antibiotics that inhibit this protein in patients with breast cancer. |
| format | Article |
| id | doaj-art-a264f076f10449a88d6547c6a19dbd7d |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-a264f076f10449a88d6547c6a19dbd7d2025-08-03T13:04:44ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01629-10475651Clinical Significance of Expression of Topoisomerase 2а in Breast CancerA. A. Samuseva0R. V. Lyubota1A. S. Zotov2R. I. Vereshchako3Bogomolets National Medical UniversityBogomolets National Medical UniversityBogomolets National Medical UniversityBogomolets National Medical UniversityTopoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an independent value of the level of expression of topoisomerase 2a in the course of chemotherapy with anthracycline antibiotics that inhibit this protein in patients with breast cancer.https://www.antibiotics-chemotherapy.ru/jour/article/view/52breast cancertopoisomerase 2aanthracycline antibiotics |
| spellingShingle | A. A. Samuseva R. V. Lyubota A. S. Zotov R. I. Vereshchako Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer Антибиотики и Химиотерапия breast cancer topoisomerase 2a anthracycline antibiotics |
| title | Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer |
| title_full | Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer |
| title_fullStr | Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer |
| title_full_unstemmed | Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer |
| title_short | Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer |
| title_sort | clinical significance of expression of topoisomerase 2а in breast cancer |
| topic | breast cancer topoisomerase 2a anthracycline antibiotics |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/52 |
| work_keys_str_mv | AT aasamuseva clinicalsignificanceofexpressionoftopoisomerase2ainbreastcancer AT rvlyubota clinicalsignificanceofexpressionoftopoisomerase2ainbreastcancer AT aszotov clinicalsignificanceofexpressionoftopoisomerase2ainbreastcancer AT rivereshchako clinicalsignificanceofexpressionoftopoisomerase2ainbreastcancer |