TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS
Twenty-six cases with secondary malignant tumors in children and adolescents receiving treatment for Hodgkin’s lymphoma and acute lymphoblastic leukemia were analyzed. In all cases the lesion had developed in an area of previous radiation treatment. The interval between the primary treatment and sec...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/191 |
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| _version_ | 1839579621103763456 |
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| author | O. I. Scherbenko R. A. Parkhomenko |
| author_facet | O. I. Scherbenko R. A. Parkhomenko |
| author_sort | O. I. Scherbenko |
| collection | DOAJ |
| description | Twenty-six cases with secondary malignant tumors in children and adolescents receiving treatment for Hodgkin’s lymphoma and acute lymphoblastic leukemia were analyzed. In all cases the lesion had developed in an area of previous radiation treatment. The interval between the primary treatment and secondary cancer development was from 3 to 29 years. The radiation therapy dose was from 12 to 45 Gy. Treatment of secondary cancer was successful only in 5 patients, the remaining patients died of disease progression. The risk of developing secondary cancer should be considered when planning treatment for patients with hemoblastosis. In cases with favorable prognosis (complete remission after induction chemotherapy and other signs of favorable prognosis) it is advisable to withhold radiation therapy as the most important risk factor for cancer. |
| format | Article |
| id | doaj-art-a1e1407f46f643b1b9d88df2f81f5c28 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-a1e1407f46f643b1b9d88df2f81f5c282025-08-04T10:33:36ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01046265191TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTSO. I. Scherbenko0R. A. Parkhomenko1Russian Scientific Center of Roentgenoradiology, MoscowRussian Scientific Center of Roentgenoradiology, MoscowTwenty-six cases with secondary malignant tumors in children and adolescents receiving treatment for Hodgkin’s lymphoma and acute lymphoblastic leukemia were analyzed. In all cases the lesion had developed in an area of previous radiation treatment. The interval between the primary treatment and secondary cancer development was from 3 to 29 years. The radiation therapy dose was from 12 to 45 Gy. Treatment of secondary cancer was successful only in 5 patients, the remaining patients died of disease progression. The risk of developing secondary cancer should be considered when planning treatment for patients with hemoblastosis. In cases with favorable prognosis (complete remission after induction chemotherapy and other signs of favorable prognosis) it is advisable to withhold radiation therapy as the most important risk factor for cancer.https://www.siboncoj.ru/jour/article/view/191radiation therapyhodgkin’s lymphomaacute lymphoblastic leukemiaradiation-induced carcinogenesis |
| spellingShingle | O. I. Scherbenko R. A. Parkhomenko TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS Сибирский онкологический журнал radiation therapy hodgkin’s lymphoma acute lymphoblastic leukemia radiation-induced carcinogenesis |
| title | TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS |
| title_full | TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS |
| title_fullStr | TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS |
| title_full_unstemmed | TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS |
| title_short | TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS |
| title_sort | to the problem of radiation induced carcinogenesis after treatment of hodgkin s lymphoma and acute lymphoblastic leukemia in children and adolescents |
| topic | radiation therapy hodgkin’s lymphoma acute lymphoblastic leukemia radiation-induced carcinogenesis |
| url | https://www.siboncoj.ru/jour/article/view/191 |
| work_keys_str_mv | AT oischerbenko totheproblemofradiationinducedcarcinogenesisaftertreatmentofhodgkinslymphomaandacutelymphoblasticleukemiainchildrenandadolescents AT raparkhomenko totheproblemofradiationinducedcarcinogenesisaftertreatmentofhodgkinslymphomaandacutelymphoblasticleukemiainchildrenandadolescents |