Evaluation of the detuning ratio as a tool to detect potential interference in LC-MSMS analysis

Objective: Tandem mass spectrometry (MS/MS) is highly specific in principle, but there is always the possibility of interference due to unexpected substances in the samples that have the identical mass transitions as the target analytes (isomeric/isobaric interferences). By recording the ion ratio (...

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Bibliographic Details
Main Authors: Arber Rexhaj, Michael Vogeser, Katharina Habler
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X25000215
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