The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals
The paper presents the results of extended preclinical studies demonstrating the safety using the direct-acting antiviral drug Riamilovir in immature white rats. Riamilovir did not show any toxic effects on the growth of animals, their fertility, behavior, hematological and biochemical parameters, a...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2023-10-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1046 |
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| author | A. U. Sabitov L. P. Larionov M. N. Dobrinskaya O. V. Ledyankina A. V. Osipenko I. E. Valamina E. V. Philippova I. M. Fatikhov |
| author_facet | A. U. Sabitov L. P. Larionov M. N. Dobrinskaya O. V. Ledyankina A. V. Osipenko I. E. Valamina E. V. Philippova I. M. Fatikhov |
| author_sort | A. U. Sabitov |
| collection | DOAJ |
| description | The paper presents the results of extended preclinical studies demonstrating the safety using the direct-acting antiviral drug Riamilovir in immature white rats. Riamilovir did not show any toxic effects on the growth of animals, their fertility, behavior, hematological and biochemical parameters, as well as morphology of visceral organs when used in a course. According to the results of the studies, Ramilovir can be recommended for multicenter clinical trials in adolescents and children of younger age groups. |
| format | Article |
| id | doaj-art-a14fbd7edb0146ccb577ea93670bdc3b |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-a14fbd7edb0146ccb577ea93670bdc3b2025-08-03T13:04:49ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902023-10-01685-62432985The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory AnimalsA. U. Sabitov0L. P. Larionov1M. N. Dobrinskaya2O. V. Ledyankina3A. V. Osipenko4I. E. Valamina5E. V. Philippova6I. M. Fatikhov7Ural State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityThe paper presents the results of extended preclinical studies demonstrating the safety using the direct-acting antiviral drug Riamilovir in immature white rats. Riamilovir did not show any toxic effects on the growth of animals, their fertility, behavior, hematological and biochemical parameters, as well as morphology of visceral organs when used in a course. According to the results of the studies, Ramilovir can be recommended for multicenter clinical trials in adolescents and children of younger age groups.https://www.antibiotics-chemotherapy.ru/jour/article/view/1046preclinical studiessafetyimmature laboratory animalsriamilovir |
| spellingShingle | A. U. Sabitov L. P. Larionov M. N. Dobrinskaya O. V. Ledyankina A. V. Osipenko I. E. Valamina E. V. Philippova I. M. Fatikhov The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals Антибиотики и Химиотерапия preclinical studies safety immature laboratory animals riamilovir |
| title | The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals |
| title_full | The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals |
| title_fullStr | The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals |
| title_full_unstemmed | The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals |
| title_short | The Results of Preclinical Studies Assessing the Effect of Riamilovir on the Reproductive Function and Postnatal Growth of Offspring in Laboratory Animals |
| title_sort | results of preclinical studies assessing the effect of riamilovir on the reproductive function and postnatal growth of offspring in laboratory animals |
| topic | preclinical studies safety immature laboratory animals riamilovir |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1046 |
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