Layilin regulates Treg motility and suppressive capacity in skin

Layilin regulates Treg motility and suppressive capacity in skin

Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin. Layilin was highly expressed on a subset of clonally expanded ‘effector’ Tregs in bo...

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Bibliographic Details
Main Authors: Victoire Gouirand, Sean Clancy, Courtney Macon, Jose Valle, Mariela Pauli, Hong-An Truong, Jarish Cohen, Maxime Kinet, Margaret M Lowe, Samuel J Lord, Kristen Skruber, Hobart Harris, Esther Kim, Isaac Neuhaus, Karin Reif, Ali A Zarrin, R Dyche Mullins, Michael D Rosenblum
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
regulatory T cell
Skin
cell adhesion
Online Access:https://elifesciences.org/articles/105277
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