Features of cytokine spectrum in chronic urticarial
Urticaria is a serious medical and social problem due to its high prevalence, lack of unified approaches to diagnosis and treatment, with high financial costs for therapy and rehabilitation. Long-term recurrent course of the disease, resistance to traditional methods of therapy lead to a significant...
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-12-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/2332 |
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| author | Т. P. Оspelnikova A. A. Denisov N. A. Cherevko V. V. Кuzmina V. S. Dmitruk D. S. Nagaitseva I. S. Каrgov |
| author_facet | Т. P. Оspelnikova A. A. Denisov N. A. Cherevko V. V. Кuzmina V. S. Dmitruk D. S. Nagaitseva I. S. Каrgov |
| author_sort | Т. P. Оspelnikova |
| collection | DOAJ |
| description | Urticaria is a serious medical and social problem due to its high prevalence, lack of unified approaches to diagnosis and treatment, with high financial costs for therapy and rehabilitation. Long-term recurrent course of the disease, resistance to traditional methods of therapy lead to a significant decrease in the quality of life of patients with chronic urticaria. Itching accompanying this disease leads to deterioration in the patient’s general well-being, frequent sleep disturbances and, as a result, significant decrease in working capacity. Up to the present moment, etiopathogenesis of urticaria is a complex challenge due to the multivector nature of cytokine response, interference of protides of the complement system, patterns of kininbradykinin interference, peculiar expression of the immune response. The problem of current population is lipotrophy – chronic, heterogeneous, cytokine mediating, progressive inflammatory disease attributed by abnormal accumulation of excessive adipose tissue. Adipose tissue, being a sporadic organ of endocrine system secretes multiple hormone-like substances, mediators, cytokines and chemokines which have been given a common name, i.e., adipokines or adipocytokines. True signs of destructive parenchymal changes of liver in the form of increasing bilirubin and AST, decreasing level of vitamin D in patients with chronic recurrent urticarial in presence of obesity have been revealed during the study performed. The action of cytokines, as mediators of intercellular interaction is closely related to the physiological and pathophysiological responses of the body with modulation of both local and systemic defense mechanisms. It is assumed that the cytokine status of patients with chronic urticaria is dominated by cytokines that increase allergic inflammation of the skin. Analysis of 12 T regulatory biomarker concentrations revealed increased concentrations of IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1 in blood serum of patients with chronic urticaria. It was found that in the group of patients with chronic urticaria and increased body mass index (BMI), the level of all investigated T regulatory cytokines is lower than in the patients with normal BMI, except for IL-10. Decreased levels of biologically active IFN I (α/β) and, especially, IFN II (γ) types of blood leukocytes in patients with chronic urticaria were revealed. The levels of 12 Treg cytokines were determined in blood serum of patients with chronic urticaria, showing trend for imbalance of Treg cytokines: IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1. |
| format | Article |
| id | doaj-art-a10b51fee3bd4eb3a20a5d622999ffa3 |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-a10b51fee3bd4eb3a20a5d622999ffa32025-08-04T14:30:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-12-012361347135610.15789/1563-0625-FOC-23321501Features of cytokine spectrum in chronic urticarialТ. P. Оspelnikova0A. A. Denisov1N. A. Cherevko2V. V. Кuzmina3V. S. Dmitruk4D. S. Nagaitseva5I. S. Каrgov6I. Mechnikov Research Institute of Vaccines and SeraSiberian State Medical UniversitySiberian State Medical University; Center of Family MedicineI. Mechnikov Research Institute of Vaccines and SeraSiberian State Medical UniversityCenter of Family MedicineBio-Rad LaboratoriesUrticaria is a serious medical and social problem due to its high prevalence, lack of unified approaches to diagnosis and treatment, with high financial costs for therapy and rehabilitation. Long-term recurrent course of the disease, resistance to traditional methods of therapy lead to a significant decrease in the quality of life of patients with chronic urticaria. Itching accompanying this disease leads to deterioration in the patient’s general well-being, frequent sleep disturbances and, as a result, significant decrease in working capacity. Up to the present moment, etiopathogenesis of urticaria is a complex challenge due to the multivector nature of cytokine response, interference of protides of the complement system, patterns of kininbradykinin interference, peculiar expression of the immune response. The problem of current population is lipotrophy – chronic, heterogeneous, cytokine mediating, progressive inflammatory disease attributed by abnormal accumulation of excessive adipose tissue. Adipose tissue, being a sporadic organ of endocrine system secretes multiple hormone-like substances, mediators, cytokines and chemokines which have been given a common name, i.e., adipokines or adipocytokines. True signs of destructive parenchymal changes of liver in the form of increasing bilirubin and AST, decreasing level of vitamin D in patients with chronic recurrent urticarial in presence of obesity have been revealed during the study performed. The action of cytokines, as mediators of intercellular interaction is closely related to the physiological and pathophysiological responses of the body with modulation of both local and systemic defense mechanisms. It is assumed that the cytokine status of patients with chronic urticaria is dominated by cytokines that increase allergic inflammation of the skin. Analysis of 12 T regulatory biomarker concentrations revealed increased concentrations of IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1 in blood serum of patients with chronic urticaria. It was found that in the group of patients with chronic urticaria and increased body mass index (BMI), the level of all investigated T regulatory cytokines is lower than in the patients with normal BMI, except for IL-10. Decreased levels of biologically active IFN I (α/β) and, especially, IFN II (γ) types of blood leukocytes in patients with chronic urticaria were revealed. The levels of 12 Treg cytokines were determined in blood serum of patients with chronic urticaria, showing trend for imbalance of Treg cytokines: IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1.https://www.mimmun.ru/mimmun/article/view/2332allergic disorderchronic urtcariabiomarkersregulatory cytokinesinterferonobesity |
| spellingShingle | Т. P. Оspelnikova A. A. Denisov N. A. Cherevko V. V. Кuzmina V. S. Dmitruk D. S. Nagaitseva I. S. Каrgov Features of cytokine spectrum in chronic urticarial Медицинская иммунология allergic disorder chronic urtcaria biomarkers regulatory cytokines interferon obesity |
| title | Features of cytokine spectrum in chronic urticarial |
| title_full | Features of cytokine spectrum in chronic urticarial |
| title_fullStr | Features of cytokine spectrum in chronic urticarial |
| title_full_unstemmed | Features of cytokine spectrum in chronic urticarial |
| title_short | Features of cytokine spectrum in chronic urticarial |
| title_sort | features of cytokine spectrum in chronic urticarial |
| topic | allergic disorder chronic urtcaria biomarkers regulatory cytokines interferon obesity |
| url | https://www.mimmun.ru/mimmun/article/view/2332 |
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