Bile acids affect intestinal barrier function through FXR and TGR5
Bile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, making bile acid metabolism a critical regulator of intestina...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1607899/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839637361271504896 |
|---|---|
| author | Guangyao Song Yuxiao Xie Yuxiao Xie Lanlan Yi Wenjie Cheng Huijin Jia Wenzhe Shi Qiwei Liu Ligui Fang Shiqi Xue Dan Liu Junhong Zhu Sumei Zhao |
| author_facet | Guangyao Song Yuxiao Xie Yuxiao Xie Lanlan Yi Wenjie Cheng Huijin Jia Wenzhe Shi Qiwei Liu Ligui Fang Shiqi Xue Dan Liu Junhong Zhu Sumei Zhao |
| author_sort | Guangyao Song |
| collection | DOAJ |
| description | Bile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, making bile acid metabolism a critical regulator of intestinal homeostasis. The intestinal epithelium prominently expresses two key bile acid receptors - the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) - which play indispensable roles in maintaining bile acid homeostasis and intestinal barrier function. Due to the abundant expression of bile acid receptors and the importance of the intestine in preventing pathogen invasion, researchers are increasingly focused on the function of bile acids in this system. This article focuses on the effect of bile acids and their receptors, FXR and the TGR5, in modulating intestinal barrier function. |
| format | Article |
| id | doaj-art-a10a90d7f9234139a309d0e67a2f17f3 |
| institution | Matheson Library |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-a10a90d7f9234139a309d0e67a2f17f32025-07-07T05:26:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16078991607899Bile acids affect intestinal barrier function through FXR and TGR5Guangyao Song0Yuxiao Xie1Yuxiao Xie2Lanlan Yi3Wenjie Cheng4Huijin Jia5Wenzhe Shi6Qiwei Liu7Ligui Fang8Shiqi Xue9Dan Liu10Junhong Zhu11Sumei Zhao12College of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Biology and Agriculture, Zunyi Normal University, Zunyi, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaBile acids play a dual role by aiding lipid absorption and acting as signaling molecules by interacting with various receptors. Bile acids are perpetually recycled via enterohepatic circulation and are biotransformation by gut microbiota, making bile acid metabolism a critical regulator of intestinal homeostasis. The intestinal epithelium prominently expresses two key bile acid receptors - the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) - which play indispensable roles in maintaining bile acid homeostasis and intestinal barrier function. Due to the abundant expression of bile acid receptors and the importance of the intestine in preventing pathogen invasion, researchers are increasingly focused on the function of bile acids in this system. This article focuses on the effect of bile acids and their receptors, FXR and the TGR5, in modulating intestinal barrier function.https://www.frontiersin.org/articles/10.3389/fmed.2025.1607899/fullbile acidsbile acid receptorsFXRTGR5intestinal barrier |
| spellingShingle | Guangyao Song Yuxiao Xie Yuxiao Xie Lanlan Yi Wenjie Cheng Huijin Jia Wenzhe Shi Qiwei Liu Ligui Fang Shiqi Xue Dan Liu Junhong Zhu Sumei Zhao Bile acids affect intestinal barrier function through FXR and TGR5 Frontiers in Medicine bile acids bile acid receptors FXR TGR5 intestinal barrier |
| title | Bile acids affect intestinal barrier function through FXR and TGR5 |
| title_full | Bile acids affect intestinal barrier function through FXR and TGR5 |
| title_fullStr | Bile acids affect intestinal barrier function through FXR and TGR5 |
| title_full_unstemmed | Bile acids affect intestinal barrier function through FXR and TGR5 |
| title_short | Bile acids affect intestinal barrier function through FXR and TGR5 |
| title_sort | bile acids affect intestinal barrier function through fxr and tgr5 |
| topic | bile acids bile acid receptors FXR TGR5 intestinal barrier |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1607899/full |
| work_keys_str_mv | AT guangyaosong bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT yuxiaoxie bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT yuxiaoxie bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT lanlanyi bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT wenjiecheng bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT huijinjia bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT wenzheshi bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT qiweiliu bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT liguifang bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT shiqixue bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT danliu bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT junhongzhu bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 AT sumeizhao bileacidsaffectintestinalbarrierfunctionthroughfxrandtgr5 |