Shenfu injection promotes self-renewal of intestinal stem cells in sepsis-induced intestinal injury via inducing ATF4 expression

Shenfu injection promotes self-renewal of intestinal stem cells in sepsis-induced intestinal injury via inducing ATF4 expression

IntroductionShenfu injection (SFI) is widely used in clinical severe conditions including sepsis due to its pharmacological effects of invigorating Qi and reviving Yang for resuscitation. SFI is known to alleviate sepsis-related intestinal injury. However, the underlying mechanism remains exclusive....

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Bibliographic Details
Main Authors: Yunxin Deng, Lingyun Lu, Jinrong Li, Liya Gao, Yihui Wang, Nataša Petrović, Fengyong Yang, You Li, Mei Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Shenfu injection
sepsis
intestinal dysfunction
crypt stem cell
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1500157/full
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