Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC
Objectives. Determination of target products and byproducts is necessary for the quality control of phthalonitrile monomer synthesis as well as production scaling and performing related kinetic studies. High-performance liquid chromatography (HPLC) is a simple and affordable method for quantitative...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2021-03-01
|
| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/1689 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839581297517789184 |
|---|---|
| author | Z. N. Shchekoldina A. A. Bogolyubov A. Yu. Zakharov B. A. Bulgakov A. V. Babkin A. V. Kepman |
| author_facet | Z. N. Shchekoldina A. A. Bogolyubov A. Yu. Zakharov B. A. Bulgakov A. V. Babkin A. V. Kepman |
| author_sort | Z. N. Shchekoldina |
| collection | DOAJ |
| description | Objectives. Determination of target products and byproducts is necessary for the quality control of phthalonitrile monomer synthesis as well as production scaling and performing related kinetic studies. High-performance liquid chromatography (HPLC) is a simple and affordable method for quantitative chemical analysis, which also verifies the quality of raw materials. The objective of this study was to develop an HPLC technique for determining the composition of the reaction mixture in the synthesis of 1,3-bis(3,4-dicyanophenoxy)benzene (DPB).Methods. Reversed-phase HPLC was used to quantitatively analyze the reaction mixture.Results. A simple and rapid method for the quantitative HPLC analysis of phthalonitrile monomers and their mixtures with reagents was developed. Reaction times and the accumulation of byproducts were also studied.Conclusions. The successful performance of the developed technique allows us to recommend it for practical applications. The results obtained for reactors of different sizes have good convergence, and DPB synthesis was successfully scaled up to intermediate scale equipment. |
| format | Article |
| id | doaj-art-a0e316a7202f45e2959d69d021c49b55 |
| institution | Matheson Library |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-a0e316a7202f45e2959d69d021c49b552025-08-04T10:19:39ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752021-03-01161889810.32362/2410-6593-2021-16-1-88-981627Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLCZ. N. Shchekoldina0A. A. Bogolyubov1A. Yu. Zakharov2B. A. Bulgakov3A. V. Babkin4A. V. Kepman5Moscow State UniversityMoscow State UniversityKurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesMoscow State UniversityMoscow State UniversityMoscow State UniversityObjectives. Determination of target products and byproducts is necessary for the quality control of phthalonitrile monomer synthesis as well as production scaling and performing related kinetic studies. High-performance liquid chromatography (HPLC) is a simple and affordable method for quantitative chemical analysis, which also verifies the quality of raw materials. The objective of this study was to develop an HPLC technique for determining the composition of the reaction mixture in the synthesis of 1,3-bis(3,4-dicyanophenoxy)benzene (DPB).Methods. Reversed-phase HPLC was used to quantitatively analyze the reaction mixture.Results. A simple and rapid method for the quantitative HPLC analysis of phthalonitrile monomers and their mixtures with reagents was developed. Reaction times and the accumulation of byproducts were also studied.Conclusions. The successful performance of the developed technique allows us to recommend it for practical applications. The results obtained for reactors of different sizes have good convergence, and DPB synthesis was successfully scaled up to intermediate scale equipment.https://www.finechem-mirea.ru/jour/article/view/16891,3-bis(3,4-dicyanophenoxy)benzenehigh-performance liquid chromatographyquantitative analysisscaling upphthalonitrile resins |
| spellingShingle | Z. N. Shchekoldina A. A. Bogolyubov A. Yu. Zakharov B. A. Bulgakov A. V. Babkin A. V. Kepman Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC Тонкие химические технологии 1,3-bis(3,4-dicyanophenoxy)benzene high-performance liquid chromatography quantitative analysis scaling up phthalonitrile resins |
| title | Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC |
| title_full | Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC |
| title_fullStr | Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC |
| title_full_unstemmed | Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC |
| title_short | Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC |
| title_sort | development of the technique for quality control of 1 3 bis 3 4 dicyanophenoxy benzene by hplc |
| topic | 1,3-bis(3,4-dicyanophenoxy)benzene high-performance liquid chromatography quantitative analysis scaling up phthalonitrile resins |
| url | https://www.finechem-mirea.ru/jour/article/view/1689 |
| work_keys_str_mv | AT znshchekoldina developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc AT aabogolyubov developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc AT ayuzakharov developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc AT babulgakov developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc AT avbabkin developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc AT avkepman developmentofthetechniqueforqualitycontrolof13bis34dicyanophenoxybenzenebyhplc |