LRO biogenesis and function: what can we learn from mast cells?

LRO biogenesis and function: what can we learn from mast cells?

Lysosome-related organelles (LROs) are specialized compartments with cell type-specific roles. In mast cells (MCs), which are tissue-localized hematopoietic effector cells, LROs refer to secretory lysosomes also known as secretory granules (SGs) containing numerous pre-formed inflammatory mediators...

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Bibliographic Details
Main Authors: Juan Eduardo Montero-Hernández, Kerui Zhang, Ulrich Blank, Gaël Ménasché
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mast cells
lysosome-related organelle (LRO)
secretory granules
LRO transport
LRO fusion
pre-formed inflammatory mediators
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1613677/full
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