Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development
Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer, neurodegenerative diseases, bacterial and myco...
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| Format: | Article |
| Language: | English |
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University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2025-12-01
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| Series: | Makedonsko Farmacevtski Bilten |
| Subjects: | |
| Online Access: | http://bulletin.mfd.org.mk/volumes/Volume%2071_2/71_2_002.pdf |
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| _version_ | 1839622987741921280 |
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| author | Aleksandar Dimkovski Evgenija Mihajloska Ana Poceva Panovska |
| author_facet | Aleksandar Dimkovski Evgenija Mihajloska Ana Poceva Panovska |
| author_sort | Aleksandar Dimkovski |
| collection | DOAJ |
| description | Isatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural
versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer, neurodegenerative diseases, bacterial and mycobacterial infections, diabetes, inflammation, and viral diseases. Rational hybridization strategies have led to compounds with enhanced potency, multitarget activity, and improved pharmacokinetic profiles. Key structural modifications, especially at the N-1, C-3, and C-5 positions of the isatin core, have been crucial in optimizing biological efficacy. Several hybrids demonstrated superior activity compared to standard drugs, alongside favorable safety and pharmacodynamic and pharmacokinetic profiles. This overview highlights the therapeutic potential of isatin hybrids as versatile scaffolds for the development of next-generation multifunctional agents across diverse clinical areas.
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| format | Article |
| id | doaj-art-a0b6a91d5ed4436c8fdc7e43d25af152 |
| institution | Matheson Library |
| issn | 1409-8695 1857-8969 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association |
| record_format | Article |
| series | Makedonsko Farmacevtski Bilten |
| spelling | doaj-art-a0b6a91d5ed4436c8fdc7e43d25af1522025-07-21T09:14:36ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1409-86951857-89692025-12-01712132510.33320/maced.pharm.bull.2025.71.02.002Recent advances in isatin-derived hybrids: promising multifunctional agents for drug developmentAleksandar Dimkovski0Evgenija Mihajloska1Ana Poceva Panovska2Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute for Pharmaceutical Chemistry, Majka Tereza 47, 1000 Skopje, Republic of North MacedoniaSs Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute for Pharmaceutical Chemistry, Majka Tereza 47, 1000 Skopje, Republic of North MacedoniaSs Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute for Applied Chemistry and Pharmaceutical Analysis, Majka Tereza 47, 1000 Skopje, Republic of North MacedoniaIsatin-based hybrids have emerged as promising candidates in medicinal chemistry due to their broad biological activities and structural versatility. This review outlines recent developments (2020–2025) in the design of isatin hybrids targeting cancer, neurodegenerative diseases, bacterial and mycobacterial infections, diabetes, inflammation, and viral diseases. Rational hybridization strategies have led to compounds with enhanced potency, multitarget activity, and improved pharmacokinetic profiles. Key structural modifications, especially at the N-1, C-3, and C-5 positions of the isatin core, have been crucial in optimizing biological efficacy. Several hybrids demonstrated superior activity compared to standard drugs, alongside favorable safety and pharmacodynamic and pharmacokinetic profiles. This overview highlights the therapeutic potential of isatin hybrids as versatile scaffolds for the development of next-generation multifunctional agents across diverse clinical areas. http://bulletin.mfd.org.mk/volumes/Volume%2071_2/71_2_002.pdfisatin derivativesdrug discoverypharmacological propertiesanticancer activityneuroprotective activity |
| spellingShingle | Aleksandar Dimkovski Evgenija Mihajloska Ana Poceva Panovska Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development Makedonsko Farmacevtski Bilten isatin derivatives drug discovery pharmacological properties anticancer activity neuroprotective activity |
| title | Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development |
| title_full | Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development |
| title_fullStr | Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development |
| title_full_unstemmed | Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development |
| title_short | Recent advances in isatin-derived hybrids: promising multifunctional agents for drug development |
| title_sort | recent advances in isatin derived hybrids promising multifunctional agents for drug development |
| topic | isatin derivatives drug discovery pharmacological properties anticancer activity neuroprotective activity |
| url | http://bulletin.mfd.org.mk/volumes/Volume%2071_2/71_2_002.pdf |
| work_keys_str_mv | AT aleksandardimkovski recentadvancesinisatinderivedhybridspromisingmultifunctionalagentsfordrugdevelopment AT evgenijamihajloska recentadvancesinisatinderivedhybridspromisingmultifunctionalagentsfordrugdevelopment AT anapocevapanovska recentadvancesinisatinderivedhybridspromisingmultifunctionalagentsfordrugdevelopment |