New Chaetoglobosins with Fungicidal Activity from <i>Chaetomium</i> sp. UJN-EF006 Endophytic in <i>Vaccinium bracteatum</i>

New Chaetoglobosins with Fungicidal Activity from <i>Chaetomium</i> sp. UJN-EF006 Endophytic in <i>Vaccinium bracteatum</i>

Nine chaetoglobosins (<b>1</b>–<b>9</b>) including five previously undescribed ones (<b>1</b>–<b>5</b>) were obtained from the culture broth of an endophytic fungus (<i>Chaetomium</i> sp. UJN-EF006) isolated from the leaves of <i>Vacc...

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Main Authors: Luo-Jing Wang, Zong-Yan Ma, Xin-Ling Wang, Kai-Le Wang, Tong Zhang, Rui-Ying Han, Jun-Jiang Li, Jie Bao, Yin-Yin Wang, Hua Zhang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Journal of Fungi
Subjects:
<i>Chaetomium</i> sp.
chaetoglobosin
phytopathogen
fungicide
<i>Botrytis cinerea</i>
<i>Sclerotinia sclerotiorum</i>
Online Access:https://www.mdpi.com/2309-608X/11/7/511
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Summary:Nine chaetoglobosins (<b>1</b>–<b>9</b>) including five previously undescribed ones (<b>1</b>–<b>5</b>) were obtained from the culture broth of an endophytic fungus (<i>Chaetomium</i> sp. UJN-EF006) isolated from the leaves of <i>Vaccinium bracteatum</i>. The structures of these fungal metabolites were elucidated by spectroscopic methods including mass spectroscopy, nuclear magnetic resonance, single crystal X-ray crystallography, and electronic circular dichroism. To accelerate the development of novel fungicides, all of the isolated chaetoglobosins were evaluated for their antifungal activity against two crop pathogens, <i>Botrytis cinerea</i> and <i>Sclerotinia sclerotiorum</i>. The assay results revealed that chaetoglobosins <b>2</b>, <b>6</b>, <b>7</b>, and <b>9</b> possessed a significant fungicidal effect against <i>B. cinerea</i>, with EC<sub>50</sub> values all below 10 μg/mL. Particularly, the most potent compound, <b>7</b>, was 175- and 96-fold as active as the commercially available fungicides carbendazim (EC<sub>50</sub> 70.11 μg/mL) and azoxystrobin (EC<sub>50</sub> 39.02 μg/mL), respectively. A further observation under scanning electron microscope indicated that compound <b>2</b> could markedly impair the fungal hyphae of <i>B. cinerea</i>. The study demonstrates that the chaetoglobosins had excellent in vitro antifungal activities against <i>B. cinerea</i>.
ISSN:2309-608X

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