ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА
In 24 patients with type 1 and 2 diabetes and 12 donors was shown that in diabetes the Nox releasing of membrane of blood formations is significantly enhanced. This phenomenon is more pronounced in type 2 diabetes, indicating a greater violation of the stability of erythrocyte membranes (EM) and ser...
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SINAPS LLC
2014-06-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/301 |
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| author | Е. А. Агаджанова |
| author_facet | Е. А. Агаджанова |
| author_sort | Е. А. Агаджанова |
| collection | DOAJ |
| description | In 24 patients with type 1 and 2 diabetes and 12 donors was shown that in diabetes the Nox releasing of membrane of blood formations is significantly enhanced. This phenomenon is more pronounced in type 2 diabetes, indicating a greater violation of the stability of erythrocyte membranes (EM) and serum exosomes (SE). Under the influence of exogenous glucose releasing of Nox is further enhanced to a greater extent, in particular from SE. Influenced insulin in vitro releasing Nox in EM and SE also increases in. Based on a number of data , it has been suggested the possible role of Nox as the insulin receptor. It is shown that in the serum membranous structures of patients with type 1 diabetes treated with insulin, as well as the addition of insulin into the blood of patients with type 2 diabetes the releasing of Nox was significantly higher than in healthy donors. In the presence of Embryonal antitumor modulator of Mkrtchyan (EATM) the releasing of Nox is significantly inhibited, especially in patients with type 2 diabetes. Suppression of the Nox isoforms releasing of EM and SE in patients with diabetes under the influence EATM can be considered as a possible mechanism of its membrane stabilizing effect in vivo. |
| format | Article |
| id | doaj-art-9fb19efb1ada4a36b50b8045c23739b3 |
| institution | Matheson Library |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-9fb19efb1ada4a36b50b8045c23739b32025-08-04T14:09:43ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642014-06-0103394510.20514/2226-6704-2014-0-3-39-45314ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРАЕ. А. Агаджанова0Ереванский государственный медицинский университет; Институт биохимии им. Г.Х. Бунятяна НАН РАIn 24 patients with type 1 and 2 diabetes and 12 donors was shown that in diabetes the Nox releasing of membrane of blood formations is significantly enhanced. This phenomenon is more pronounced in type 2 diabetes, indicating a greater violation of the stability of erythrocyte membranes (EM) and serum exosomes (SE). Under the influence of exogenous glucose releasing of Nox is further enhanced to a greater extent, in particular from SE. Influenced insulin in vitro releasing Nox in EM and SE also increases in. Based on a number of data , it has been suggested the possible role of Nox as the insulin receptor. It is shown that in the serum membranous structures of patients with type 1 diabetes treated with insulin, as well as the addition of insulin into the blood of patients with type 2 diabetes the releasing of Nox was significantly higher than in healthy donors. In the presence of Embryonal antitumor modulator of Mkrtchyan (EATM) the releasing of Nox is significantly inhibited, especially in patients with type 2 diabetes. Suppression of the Nox isoforms releasing of EM and SE in patients with diabetes under the influence EATM can be considered as a possible mechanism of its membrane stabilizing effect in vivo.https://www.medarhive.ru/jour/article/view/301diabetes mellitusnoxglucoseinsulinmkrtchyan embryonic antitumor modulator |
| spellingShingle | Е. А. Агаджанова ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА Архивъ внутренней медицины diabetes mellitus nox glucose insulin mkrtchyan embryonic antitumor modulator |
| title | ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА |
| title_full | ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА |
| title_fullStr | ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА |
| title_full_unstemmed | ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА |
| title_short | ВЛИЯНИЕ ГЛЮКОЗЫ И ИНСУЛИНА НА АКТИВНОСТЬ NOX В КРОВИ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ И РЕГУЛЯЦИЯ ЕЁ ПОСРЕДСТВОМ ЭМБРИОНАЛЬНОГО ПРОТИВООПУХОЛЕВОГО МОДУЛЯТОРА |
| title_sort | влияние глюкозы и инсулина на активность nox в крови больных сахарным диабетом и регуляция её посредством эмбрионального противоопухолевого модулятора |
| topic | diabetes mellitus nox glucose insulin mkrtchyan embryonic antitumor modulator |
| url | https://www.medarhive.ru/jour/article/view/301 |
| work_keys_str_mv | AT eaagadžanova vliânieglûkozyiinsulinanaaktivnostʹnoxvkrovibolʹnyhsaharnymdiabetomiregulâciâeëposredstvomémbrionalʹnogoprotivoopuholevogomodulâtora |