Biocatalysis has been used in industrial settings, especially in the pharmaceutical industry, for decades. In this review, we showcase the six most prominent enzyme classes in industrial biocatalysis: keto-reductases, ene-reductases, imine-reductases, transaminases, oxygenases, and hydrolases. For e...
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| Format: | Article |
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Académie des sciences
2025-07-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.408/ |
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| author | Gilio, Amelia K. Abdo, Miguel A. Martinez, Carlos A. Palaia, Andrew T. Livada, Jovan |
| author_facet | Gilio, Amelia K. Abdo, Miguel A. Martinez, Carlos A. Palaia, Andrew T. Livada, Jovan |
| author_sort | Gilio, Amelia K. |
| collection | DOAJ |
| description | Biocatalysis has been used in industrial settings, especially in the pharmaceutical industry, for decades. In this review, we showcase the six most prominent enzyme classes in industrial biocatalysis: keto-reductases, ene-reductases, imine-reductases, transaminases, oxygenases, and hydrolases. For each class, several examples are presented that highlight the substrate scope and enantioselectivity of these biotransformations from milligram to multikilogram scale. |
| format | Article |
| id | doaj-art-9f7ca67478bb4d13be1a0539b92f4ddf |
| institution | Matheson Library |
| issn | 1878-1543 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-9f7ca67478bb4d13be1a0539b92f4ddf2025-08-01T07:30:59ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432025-07-0128G162565010.5802/crchim.40810.5802/crchim.408Gilio, Amelia K.0https://orcid.org/0000-0003-2834-035XAbdo, Miguel A.1Martinez, Carlos A.2Palaia, Andrew T.3Livada, Jovan4Pfizer Global Research and Development, Groton, CT, 06340, USAPfizer Global Research and Development, Groton, CT, 06340, USAPfizer Global Research and Development, Groton, CT, 06340, USAPfizer Global Research and Development, Groton, CT, 06340, USAPfizer Global Research and Development, Groton, CT, 06340, USABiocatalysis has been used in industrial settings, especially in the pharmaceutical industry, for decades. In this review, we showcase the six most prominent enzyme classes in industrial biocatalysis: keto-reductases, ene-reductases, imine-reductases, transaminases, oxygenases, and hydrolases. For each class, several examples are presented that highlight the substrate scope and enantioselectivity of these biotransformations from milligram to multikilogram scale.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.408/EnzymeBiocatalysisHydrolaseKetoreductaseImine-reductaseEne-reductaseTransaminase |
| spellingShingle | Gilio, Amelia K. Abdo, Miguel A. Martinez, Carlos A. Palaia, Andrew T. Livada, Jovan Comptes Rendus. Chimie Enzyme Biocatalysis Hydrolase Ketoreductase Imine-reductase Ene-reductase Transaminase |
| topic | Enzyme Biocatalysis Hydrolase Ketoreductase Imine-reductase Ene-reductase Transaminase |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.408/ |