Metabolic Reprogramming in Melanoma: An Epigenetic Point of View
Metabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. In melanoma, high metabolic-epigenetic plasticity enables the rapid modulation of cell states in response to environmental and therapeutic pressures....
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MDPI AG
2025-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/6/853 |
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| author | Stefano Giuliani Celeste Accetta Simona di Martino Claudia De Vitis Elena Messina Edoardo Pescarmona Maurizio Fanciulli Gennaro Ciliberto Rita Mancini Italia Falcone |
| author_facet | Stefano Giuliani Celeste Accetta Simona di Martino Claudia De Vitis Elena Messina Edoardo Pescarmona Maurizio Fanciulli Gennaro Ciliberto Rita Mancini Italia Falcone |
| author_sort | Stefano Giuliani |
| collection | DOAJ |
| description | Metabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. In melanoma, high metabolic-epigenetic plasticity enables the rapid modulation of cell states in response to environmental and therapeutic pressures. Recent studies have highlighted a bidirectional crosstalk between cellular metabolism and epigenetic regulation. Epigenetic modifications influence the transcriptional control of metabolic genes, thereby shaping metabolic phenotypes. Conversely, specific metabolites are essential cofactors or substrates for epigenetic enzymes, directly modulating the epigenome. Understanding the intricate mechanisms of this interaction offers opportunities for the development of innovative tumor management that combines epigenetic, metabolic, and therapy interventions. In this review, we summarize the latest evidence on the role of the metabolism–epigenetics axis in melanoma and discuss its potential clinical implications, aiming to provide a comprehensive overview of metabolic/epigenetic interconnections. |
| format | Article |
| id | doaj-art-9f4a8c80097043e4ab8e256d0370a7dd |
| institution | Matheson Library |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-9f4a8c80097043e4ab8e256d0370a7dd2025-06-25T14:17:43ZengMDPI AGPharmaceuticals1424-82472025-06-0118685310.3390/ph18060853Metabolic Reprogramming in Melanoma: An Epigenetic Point of ViewStefano Giuliani0Celeste Accetta1Simona di Martino2Claudia De Vitis3Elena Messina4Edoardo Pescarmona5Maurizio Fanciulli6Gennaro Ciliberto7Rita Mancini8Italia Falcone9SAFU, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalySAFU, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalyTakis s.r.l., Via di Castel Romano 100, 00128 Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, “Sapienza” University of Rome, 00161 Rome, ItalySAFU, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, ItalyMetabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. In melanoma, high metabolic-epigenetic plasticity enables the rapid modulation of cell states in response to environmental and therapeutic pressures. Recent studies have highlighted a bidirectional crosstalk between cellular metabolism and epigenetic regulation. Epigenetic modifications influence the transcriptional control of metabolic genes, thereby shaping metabolic phenotypes. Conversely, specific metabolites are essential cofactors or substrates for epigenetic enzymes, directly modulating the epigenome. Understanding the intricate mechanisms of this interaction offers opportunities for the development of innovative tumor management that combines epigenetic, metabolic, and therapy interventions. In this review, we summarize the latest evidence on the role of the metabolism–epigenetics axis in melanoma and discuss its potential clinical implications, aiming to provide a comprehensive overview of metabolic/epigenetic interconnections.https://www.mdpi.com/1424-8247/18/6/853melanomametabolismepigeneticsdrug resistancetarget therapyimmunotherapy |
| spellingShingle | Stefano Giuliani Celeste Accetta Simona di Martino Claudia De Vitis Elena Messina Edoardo Pescarmona Maurizio Fanciulli Gennaro Ciliberto Rita Mancini Italia Falcone Metabolic Reprogramming in Melanoma: An Epigenetic Point of View Pharmaceuticals melanoma metabolism epigenetics drug resistance target therapy immunotherapy |
| title | Metabolic Reprogramming in Melanoma: An Epigenetic Point of View |
| title_full | Metabolic Reprogramming in Melanoma: An Epigenetic Point of View |
| title_fullStr | Metabolic Reprogramming in Melanoma: An Epigenetic Point of View |
| title_full_unstemmed | Metabolic Reprogramming in Melanoma: An Epigenetic Point of View |
| title_short | Metabolic Reprogramming in Melanoma: An Epigenetic Point of View |
| title_sort | metabolic reprogramming in melanoma an epigenetic point of view |
| topic | melanoma metabolism epigenetics drug resistance target therapy immunotherapy |
| url | https://www.mdpi.com/1424-8247/18/6/853 |
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