Emerging frontiers in epigenetic-targeted therapeutics for pediatric neuroblastoma

Emerging frontiers in epigenetic-targeted therapeutics for pediatric neuroblastoma

Neuroblastoma (NB), the most prevalent extracranial solid malignancy in children, poses significant therapeutic challenges, particularly concerning high-risk subtypes characterized by an immunologically “cold” phenotype. These tumors evade immune surveillance through mechanisms such as impaired anti...

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Bibliographic Details
Main Authors: Xiaokang Wang, Gengrui Xu, Hongyan Ma, Xiaoyan Deng, Guiping Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
immunologically cold
small-molecule targeted agents
epigenetic regulation
pediatric neuroblastoma
therapeutic strategies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637626/full
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