Perturbation response scanning of drug-target networks: Drug repurposing for multiple sclerosis

Perturbation response scanning of drug-target networks: Drug repurposing for multiple sclerosis

Combined with elastic network model (ENM), the perturbation response scanning (PRS) has emerged as a robust technique for pinpointing allosteric interactions within proteins. Here, we proposed the PRS analysis of drug-target networks (DTNs), which could provide a promising avenue in network medicine...

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Bibliographic Details
Main Authors: Yitan Lu, Ziyun Zhou, Qi Li, Bin Yang, Xing Xu, Yu Zhu, Mengjun Xie, Yuwan Qi, Fei Xiao, Wenying Yan, Zhongjie Liang, Qifei Cong, Guang Hu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Network perturbations
Mechanism of action
Multiple sclerosis
HTR2B
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177925001121
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http://www.sciencedirect.com/science/article/pii/S2095177925001121

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