Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium
Abstract The associations between childhood acute lymphoblastic leukemia (ALL) and several factors related to early stimulation of the immune system, that is, farm residence and regular contacts with farm animals (livestock, poultry) or pets in early childhood, were investigated using data from 13 c...
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2018-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1466 |
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| author | Laurent Orsi Corrado Magnani Eleni T. Petridou John D. Dockerty Catherine Metayer Elizabeth Milne Helen D. Bailey Nick Dessypris Alice Y. Kang Catharina Wesseling Claire Infante‐Rivard Victor Wünsch‐Filho Ana M. Mora Logan G. Spector Jacqueline Clavel |
| author_facet | Laurent Orsi Corrado Magnani Eleni T. Petridou John D. Dockerty Catherine Metayer Elizabeth Milne Helen D. Bailey Nick Dessypris Alice Y. Kang Catharina Wesseling Claire Infante‐Rivard Victor Wünsch‐Filho Ana M. Mora Logan G. Spector Jacqueline Clavel |
| author_sort | Laurent Orsi |
| collection | DOAJ |
| description | Abstract The associations between childhood acute lymphoblastic leukemia (ALL) and several factors related to early stimulation of the immune system, that is, farm residence and regular contacts with farm animals (livestock, poultry) or pets in early childhood, were investigated using data from 13 case–control studies participating in the Childhood Leukemia International Consortium. The sample included 7847 ALL cases and 11,667 controls aged 1–14 years. In all studies, the data were obtained from case and control parents using standardized questionnaires. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Contact with livestock in the first year of life was inversely associated with ALL (OR = 0.65, 95% CI: 0.50, 0.85). Inverse associations were also observed for contact with dogs (OR = 0.92, 95% CI: 0.86, 0.99) and cats (OR = 0.87, 95% CI: 0.80, 0.94) in the first year of life. There was no evidence of a significant association with farm residence in the first year of life. The findings of these large pooled and meta‐analyses add additional evidence to the hypothesis that regular contact with animals in early childhood is inversely associated with childhood ALL occurrence which is consistent with Greaves’ delayed infection hypothesis. |
| format | Article |
| id | doaj-art-9ece33a2bcaf443885db10b43d6854ef |
| institution | Matheson Library |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-9ece33a2bcaf443885db10b43d6854ef2025-06-30T08:26:40ZengWileyCancer Medicine2045-76342018-06-01762665268110.1002/cam4.1466Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International ConsortiumLaurent Orsi0Corrado Magnani1Eleni T. Petridou2John D. Dockerty3Catherine Metayer4Elizabeth Milne5Helen D. Bailey6Nick Dessypris7Alice Y. Kang8Catharina Wesseling9Claire Infante‐Rivard10Victor Wünsch‐Filho11Ana M. Mora12Logan G. Spector13Jacqueline Clavel14INSERM U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) Epidemiology of Childhood and Adolescent Cancers Team (EPICEA) Paris‐Descartes University Villejuif FranceDipartimento di Medicina Traslazionale Università del Piemonte Orientale AOUMaggiore della Carità & CPO Piemonte Novara ItalyDepartment of Hygiene, Epidemiology, and Medical Statistics School of Medicine University of Athens Athens GreeceDepartment of Preventive and Social Medicine Dunedin School of Medicine University of Otago Dunedin New ZealandSchool of Public Health University of California Berkeley CaliforniaTelethon Kids Institute University of Western Australia Perth Western Australia AustraliaINSERM U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) Epidemiology of Childhood and Adolescent Cancers Team (EPICEA) Paris‐Descartes University Villejuif FranceDepartment of Hygiene, Epidemiology, and Medical Statistics School of Medicine University of Athens Athens GreeceSchool of Public Health University of California Berkeley CaliforniaUnit of Occupational Medicine Institute of Environmental Medicine Karolinska Institutet Stockholm SwedenDepartment of Epidemiology, Biostatistics, and Occupational Health Faculty of Medicine McGill University Montréal Quebec CanadaSchool of Public Health University of Saõ Paulo Saõ Paulo BrazilCentral American Institute for Studies on Toxic Substances (IRET) Universidad Nacional Heredia Costa RicaDivision of Epidemiology and Clinical Research Department of Pediatrics and Masonic Cancer Center University of Minnesota Minneapolis MinnesotaINSERM U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) Epidemiology of Childhood and Adolescent Cancers Team (EPICEA) Paris‐Descartes University Villejuif FranceAbstract The associations between childhood acute lymphoblastic leukemia (ALL) and several factors related to early stimulation of the immune system, that is, farm residence and regular contacts with farm animals (livestock, poultry) or pets in early childhood, were investigated using data from 13 case–control studies participating in the Childhood Leukemia International Consortium. The sample included 7847 ALL cases and 11,667 controls aged 1–14 years. In all studies, the data were obtained from case and control parents using standardized questionnaires. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Contact with livestock in the first year of life was inversely associated with ALL (OR = 0.65, 95% CI: 0.50, 0.85). Inverse associations were also observed for contact with dogs (OR = 0.92, 95% CI: 0.86, 0.99) and cats (OR = 0.87, 95% CI: 0.80, 0.94) in the first year of life. There was no evidence of a significant association with farm residence in the first year of life. The findings of these large pooled and meta‐analyses add additional evidence to the hypothesis that regular contact with animals in early childhood is inversely associated with childhood ALL occurrence which is consistent with Greaves’ delayed infection hypothesis.https://doi.org/10.1002/cam4.1466Animalschildhood leukemiacontactfarm residence |
| spellingShingle | Laurent Orsi Corrado Magnani Eleni T. Petridou John D. Dockerty Catherine Metayer Elizabeth Milne Helen D. Bailey Nick Dessypris Alice Y. Kang Catharina Wesseling Claire Infante‐Rivard Victor Wünsch‐Filho Ana M. Mora Logan G. Spector Jacqueline Clavel Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium Cancer Medicine Animals childhood leukemia contact farm residence |
| title | Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium |
| title_full | Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium |
| title_fullStr | Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium |
| title_full_unstemmed | Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium |
| title_short | Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium |
| title_sort | living on a farm contact with farm animals and pets and childhood acute lymphoblastic leukemia pooled and meta analyses from the childhood leukemia international consortium |
| topic | Animals childhood leukemia contact farm residence |
| url | https://doi.org/10.1002/cam4.1466 |
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