Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis
Leptospirosis is a global zoonotic disease affecting humans, wildlife, companion, and domestic animals. Incidental hosts can contract the disease directly or indirectly from asymptomatic reservoir hosts, most commonly small rodents. The Golden Syrian hamster is recognized as the dominant rodent mod...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-07-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/7/24-1579_article |
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| author | Ellie J. Putz Claire B. Andreasen Paola Boggiatto Mitchell V. Palmer Luis G.V. Fernandes Bienvenido W. Tibbs-Cortes Judith A. Stasko Camila Hamond Steven C. Olsen Jarlath E. Nally |
| author_facet | Ellie J. Putz Claire B. Andreasen Paola Boggiatto Mitchell V. Palmer Luis G.V. Fernandes Bienvenido W. Tibbs-Cortes Judith A. Stasko Camila Hamond Steven C. Olsen Jarlath E. Nally |
| author_sort | Ellie J. Putz |
| collection | DOAJ |
| description |
Leptospirosis is a global zoonotic disease affecting humans, wildlife, companion, and domestic animals. Incidental hosts can contract the disease directly or indirectly from asymptomatic reservoir hosts, most commonly small rodents. The Golden Syrian hamster is recognized as the dominant rodent model for acute leptospirosis because the animals are susceptible to many serovars and are used to maintain laboratory strains and test bacterin vaccine efficacy. However, hamsters are primarily used in survival-based studies, and investigations into host immune response and disease pathogenesis are limited. We found that Peromyscus leucopus white-footed deer mice are susceptible to acute leptospirosis, and thus might be an alternative rodent model. Furthermore, similar to hamsters, deer mice produce circulating foamy macrophages in response to Leptospira challenge. Deer mice exhibit differences in response to different serovars, clinical disease severity, kidney and liver lesions, and an overall sex effect, with male mice demonstrating more severe clinical signs and higher bacterial burden.
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| format | Article |
| id | doaj-art-9ea5553f54b54cabbb00ff7b1e38ab9c |
| institution | Matheson Library |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-9ea5553f54b54cabbb00ff7b1e38ab9c2025-06-25T14:59:21ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-07-013171365137610.3201/eid3107.241579Peromyscus spp. Deer Mice as Rodent Model of Acute LeptospirosisEllie J. PutzClaire B. AndreasenPaola BoggiattoMitchell V. PalmerLuis G.V. FernandesBienvenido W. Tibbs-CortesJudith A. StaskoCamila HamondSteven C. OlsenJarlath E. Nally Leptospirosis is a global zoonotic disease affecting humans, wildlife, companion, and domestic animals. Incidental hosts can contract the disease directly or indirectly from asymptomatic reservoir hosts, most commonly small rodents. The Golden Syrian hamster is recognized as the dominant rodent model for acute leptospirosis because the animals are susceptible to many serovars and are used to maintain laboratory strains and test bacterin vaccine efficacy. However, hamsters are primarily used in survival-based studies, and investigations into host immune response and disease pathogenesis are limited. We found that Peromyscus leucopus white-footed deer mice are susceptible to acute leptospirosis, and thus might be an alternative rodent model. Furthermore, similar to hamsters, deer mice produce circulating foamy macrophages in response to Leptospira challenge. Deer mice exhibit differences in response to different serovars, clinical disease severity, kidney and liver lesions, and an overall sex effect, with male mice demonstrating more severe clinical signs and higher bacterial burden. https://wwwnc.cdc.gov/eid/article/31/7/24-1579_articleleptospirosiszoonosesbacteriaLeptospira interrogansLeptospira borgpeterseniifoam cells |
| spellingShingle | Ellie J. Putz Claire B. Andreasen Paola Boggiatto Mitchell V. Palmer Luis G.V. Fernandes Bienvenido W. Tibbs-Cortes Judith A. Stasko Camila Hamond Steven C. Olsen Jarlath E. Nally Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis Emerging Infectious Diseases leptospirosis zoonoses bacteria Leptospira interrogans Leptospira borgpetersenii foam cells |
| title | Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis |
| title_full | Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis |
| title_fullStr | Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis |
| title_full_unstemmed | Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis |
| title_short | Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis |
| title_sort | peromyscus spp deer mice as rodent model of acute leptospirosis |
| topic | leptospirosis zoonoses bacteria Leptospira interrogans Leptospira borgpetersenii foam cells |
| url | https://wwwnc.cdc.gov/eid/article/31/7/24-1579_article |
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