Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy
Abstract Blue rubber bleb nevus syndrome (BRBNS) and cutaneomucosal venous malformation (VMCM) both manifest as venous malformations (VMs) characterized by blue, compressible nodules. While BRBNS typically involves visceral organs, particularly the gastrointestinal (GI) tract, VMCM has conventionall...
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BMC
2025-06-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-025-00486-5 |
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| author | Jiaxue Zhu Wei Liu Zehua Zhang Bensong Duan Xiaohan Yan |
| author_facet | Jiaxue Zhu Wei Liu Zehua Zhang Bensong Duan Xiaohan Yan |
| author_sort | Jiaxue Zhu |
| collection | DOAJ |
| description | Abstract Blue rubber bleb nevus syndrome (BRBNS) and cutaneomucosal venous malformation (VMCM) both manifest as venous malformations (VMs) characterized by blue, compressible nodules. While BRBNS typically involves visceral organs, particularly the gastrointestinal (GI) tract, VMCM has conventionally been considered to spare internal organs. Our findings, however, reveal that VMCM can indeed extend to the GI system and demonstrate that endoscopic sclerotherapy is safe and effective for its management. This underscores the importance of genetic testing and systemic evaluation in patients with multifocal VMs, suggesting the need for revised diagnostic criteria and a more nuanced approach to classification of these disorders. |
| format | Article |
| id | doaj-art-9e60142f53a04e7f9fb63f719e10e904 |
| institution | Matheson Library |
| issn | 1601-5223 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-9e60142f53a04e7f9fb63f719e10e9042025-06-29T11:11:44ZengBMCHereditas1601-52232025-06-0116211410.1186/s41065-025-00486-5Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapyJiaxue Zhu0Wei Liu1Zehua Zhang2Bensong Duan3Xiaohan Yan4Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji UniversityEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji UniversityEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji UniversityEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji UniversityAbstract Blue rubber bleb nevus syndrome (BRBNS) and cutaneomucosal venous malformation (VMCM) both manifest as venous malformations (VMs) characterized by blue, compressible nodules. While BRBNS typically involves visceral organs, particularly the gastrointestinal (GI) tract, VMCM has conventionally been considered to spare internal organs. Our findings, however, reveal that VMCM can indeed extend to the GI system and demonstrate that endoscopic sclerotherapy is safe and effective for its management. This underscores the importance of genetic testing and systemic evaluation in patients with multifocal VMs, suggesting the need for revised diagnostic criteria and a more nuanced approach to classification of these disorders.https://doi.org/10.1186/s41065-025-00486-5Cutaneomucosal venous malformationEndoscopic SclerotherapyTEKBlue Rubber Bleb Nevus Syndrome |
| spellingShingle | Jiaxue Zhu Wei Liu Zehua Zhang Bensong Duan Xiaohan Yan Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy Hereditas Cutaneomucosal venous malformation Endoscopic Sclerotherapy TEK Blue Rubber Bleb Nevus Syndrome |
| title | Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy |
| title_full | Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy |
| title_fullStr | Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy |
| title_full_unstemmed | Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy |
| title_short | Managing gastrointestinal involvement in cutaneomucosal venous malformation: safety and efficacy of endoscopic sclerotherapy |
| title_sort | managing gastrointestinal involvement in cutaneomucosal venous malformation safety and efficacy of endoscopic sclerotherapy |
| topic | Cutaneomucosal venous malformation Endoscopic Sclerotherapy TEK Blue Rubber Bleb Nevus Syndrome |
| url | https://doi.org/10.1186/s41065-025-00486-5 |
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