Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation
Background: Patients with atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular mortality compared to patients with AF alone. Consequently, employing rhythm control strategies such as AF catheter ablation could offer substantial benefits to...
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Elsevier
2025-05-01
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| Series: | Indian Pacing and Electrophysiology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0972629225000506 |
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| author | Ree Lu Devin Skoll Ahmed Y. Gasmelseed Geoffrey A. Rubin Elaine Y. Wan Amardeep S. Saluja Jose M. Dizon Angelo B. Biviano Hasan Garan Hirad Yarmohammadi |
| author_facet | Ree Lu Devin Skoll Ahmed Y. Gasmelseed Geoffrey A. Rubin Elaine Y. Wan Amardeep S. Saluja Jose M. Dizon Angelo B. Biviano Hasan Garan Hirad Yarmohammadi |
| author_sort | Ree Lu |
| collection | DOAJ |
| description | Background: Patients with atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular mortality compared to patients with AF alone. Consequently, employing rhythm control strategies such as AF catheter ablation could offer substantial benefits to patients with COPD. However, the impact of COPD on AF ablation outcomes is not well established. Methods: In this single-center case control study, we retrospectively analyzed 200 patients with AF and COPD, 52 of whom underwent AF catheter ablation. Those who underwent ablation were matched with a control group of patients with AF but without COPD who underwent ablation. Ablation outcomes were compared between the groups. Univariate and multivariable analysis were conducted for prediction of AF recurrence. Results: Compared to the controls, cases with COPD were more likely to have AF recurrence following catheter ablation (OR 13.42, P-value = 0.0001). Multivariable analysis revealed predictors of AF recurrence following catheter ablation included decreased use of loop diuretics and amiodarone. Patients with severe or very severe COPD were more likely to have left atrial enlargement than patients with mild or moderate COPD (OR 2.28, P-value = 0.026). Conclusion: Patients with AF and COPD were more likely than patients with AF but without COPD to experience AF recurrence following catheter ablation. Predictors of AF recurrence included decreased use of loop diuretics and amiodarone. Our study demonstrates that while ablation in patients with COPD is safe, ablation in patients with COPD is associated with higher AF recurrence rates. |
| format | Article |
| id | doaj-art-9d892d28fca74fb6b06b7182418c55a7 |
| institution | Matheson Library |
| issn | 0972-6292 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Pacing and Electrophysiology Journal |
| spelling | doaj-art-9d892d28fca74fb6b06b7182418c55a72025-06-28T05:29:20ZengElsevierIndian Pacing and Electrophysiology Journal0972-62922025-05-01253148156Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablationRee Lu0Devin Skoll1Ahmed Y. Gasmelseed2Geoffrey A. Rubin3Elaine Y. Wan4Amardeep S. Saluja5Jose M. Dizon6Angelo B. Biviano7Hasan Garan8Hirad Yarmohammadi9Department of Medicine, Columbia University Irving Medical Center, New York, NY, USADepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USADivision of Cardiology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; Corresponding author. Columbia University Irving Medical Center 177 Fort Washington Avenue, Room 637 New York, NY, 10032, USA.Background: Patients with atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular mortality compared to patients with AF alone. Consequently, employing rhythm control strategies such as AF catheter ablation could offer substantial benefits to patients with COPD. However, the impact of COPD on AF ablation outcomes is not well established. Methods: In this single-center case control study, we retrospectively analyzed 200 patients with AF and COPD, 52 of whom underwent AF catheter ablation. Those who underwent ablation were matched with a control group of patients with AF but without COPD who underwent ablation. Ablation outcomes were compared between the groups. Univariate and multivariable analysis were conducted for prediction of AF recurrence. Results: Compared to the controls, cases with COPD were more likely to have AF recurrence following catheter ablation (OR 13.42, P-value = 0.0001). Multivariable analysis revealed predictors of AF recurrence following catheter ablation included decreased use of loop diuretics and amiodarone. Patients with severe or very severe COPD were more likely to have left atrial enlargement than patients with mild or moderate COPD (OR 2.28, P-value = 0.026). Conclusion: Patients with AF and COPD were more likely than patients with AF but without COPD to experience AF recurrence following catheter ablation. Predictors of AF recurrence included decreased use of loop diuretics and amiodarone. Our study demonstrates that while ablation in patients with COPD is safe, ablation in patients with COPD is associated with higher AF recurrence rates.http://www.sciencedirect.com/science/article/pii/S0972629225000506Atrial fibrillationLeft atriumChronic obstructive pulmonary diseaseCatheter ablation |
| spellingShingle | Ree Lu Devin Skoll Ahmed Y. Gasmelseed Geoffrey A. Rubin Elaine Y. Wan Amardeep S. Saluja Jose M. Dizon Angelo B. Biviano Hasan Garan Hirad Yarmohammadi Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation Indian Pacing and Electrophysiology Journal Atrial fibrillation Left atrium Chronic obstructive pulmonary disease Catheter ablation |
| title | Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| title_full | Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| title_fullStr | Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| title_full_unstemmed | Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| title_short | Chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| title_sort | chronic obstructive pulmonary disease is associated with higher recurrence rates of atrial fibrillation following catheter ablation |
| topic | Atrial fibrillation Left atrium Chronic obstructive pulmonary disease Catheter ablation |
| url | http://www.sciencedirect.com/science/article/pii/S0972629225000506 |
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