The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study
Objectives: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants. Methods: Data was collected within the prospective...
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Elsevier
2025-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001973 |
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| author | Johan Berg Karolina Linden Mehreen Zaigham Magnus Domellöf Fredrik Ahlsson Anders Elfvin Ulrika Åden Thomas Abrahamsson Andreas Ohlin Johannna Berg Linda Hjertberg Sofie Graner Sophia Brismar Wendel Linda Iorizzo Sofie Arnkil Ylva Carlsson Malin Veje Lina Bergman Verena Sengpiel Ola Andersson |
| author_facet | Johan Berg Karolina Linden Mehreen Zaigham Magnus Domellöf Fredrik Ahlsson Anders Elfvin Ulrika Åden Thomas Abrahamsson Andreas Ohlin Johannna Berg Linda Hjertberg Sofie Graner Sophia Brismar Wendel Linda Iorizzo Sofie Arnkil Ylva Carlsson Malin Veje Lina Bergman Verena Sengpiel Ola Andersson |
| author_sort | Johan Berg |
| collection | DOAJ |
| description | Objectives: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants. Methods: Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed to maternal SARS-CoV-2 infection from conception until two days postpartum and unexposed controls were included June 2020-December 2022. Primary outcome: four-month-old infant neurodevelopment, measured using the Ages and Stages Questionnaire 3rd Edition (ASQ) total mean scores. Secondary outcomes: Scores below cutoff for total ASQ or the ASQ domains. Results: Of 2453 enrolled infants, 1446 (555 exposed and 891 unexposed) had available ASQ data. In adjusted regression models, there was no group difference in ASQ total mean scores. Exposed infants had lower risk of fine motor domain scores below cutoff (exposed: 4.0% vs. unexposed: 6.6%; adjusted odds ratio (aOR), 0.55; 95% CI, 0.33-0.92). Infants exposed to severe maternal COVID-19 had increased risk of total ASQ scores below cutoff (exposed: 16.0% vs. unexposed: 6.1%; aOR, 3.57; 95% CI, 1.14-11.24). Conclusions: Antenatal maternal SARS-CoV-2 infection was not associated with overall impaired four-month infant neurodevelopmental screening. In exploratory analyses, severe maternal COVID-19 was associated with abnormal screening results. |
| format | Article |
| id | doaj-art-9d4fa0986daa45da943f87c41e93f95a |
| institution | Matheson Library |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-9d4fa0986daa45da943f87c41e93f95a2025-08-04T04:23:55ZengElsevierInternational Journal of Infectious Diseases1201-97122025-09-01158107973The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE studyJohan Berg0Karolina Linden1Mehreen Zaigham2Magnus Domellöf3Fredrik Ahlsson4Anders Elfvin5Ulrika Åden6Thomas Abrahamsson7Andreas Ohlin8Johannna Berg9Linda Hjertberg10Sofie Graner11Sophia Brismar Wendel12Linda Iorizzo13Sofie Arnkil14Ylva Carlsson15Malin Veje16Lina Bergman17Verena Sengpiel18Ola Andersson19Department of Neonatology, Skåne University Hospital, Malmö/Lund, Sweden; Department of Clinical Sciences Lund, Pediatrics, Lund University, Lund, Sweden; Corresponding author. Johan Berg, Department of Neonatology and Child Surgery, Skåne University Hospital, Klinikgatan, 12, 221 85 Lund, Sweden.Sahlgrenska Academy, Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, SwedenDepartment of Clinical Sciences Malmö, Obstetrics and Gynaecology, Lund University and Skåne University Hospital, Malmö, SwedenDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, SwedenDepartment of Women´s and Children’s Health, Uppsala University, Uppsala, SwedenDepartment of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Department of Pediatrics, The Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden; Neonatal Unit, Karolinska University Hospital, Solna, SwedenDepartment of Biomedical and Clinical Sciences, Linköping University and Crown Princess Victoria Children’s Hospital, Linköping, SwedenDepartment of Pediatrics, Faculty of Medicine and Health, Örebro University, Örebro, SwedenDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Department of Obstetrics and Gynaecology, NU Hospital Group, Trollhättan, SwedenDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Obstetrics and Gynecology, Vrinnevihospital, Norrköping, SwedenCentre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Solna, SwedenDepartment of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenDepartment of Clinical Sciences Lund, Obstetrics and Gynaecology, Lund University and Skåne University Hospital, Lund, SwedenDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynaecology, Gothenburg, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynaecology, Gothenburg, SwedenDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynaecology, Gothenburg, SwedenDepartment of Neonatology, Skåne University Hospital, Malmö/Lund, Sweden; Department of Clinical Sciences Lund, Pediatrics, Lund University, Lund, SwedenObjectives: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants. Methods: Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed to maternal SARS-CoV-2 infection from conception until two days postpartum and unexposed controls were included June 2020-December 2022. Primary outcome: four-month-old infant neurodevelopment, measured using the Ages and Stages Questionnaire 3rd Edition (ASQ) total mean scores. Secondary outcomes: Scores below cutoff for total ASQ or the ASQ domains. Results: Of 2453 enrolled infants, 1446 (555 exposed and 891 unexposed) had available ASQ data. In adjusted regression models, there was no group difference in ASQ total mean scores. Exposed infants had lower risk of fine motor domain scores below cutoff (exposed: 4.0% vs. unexposed: 6.6%; adjusted odds ratio (aOR), 0.55; 95% CI, 0.33-0.92). Infants exposed to severe maternal COVID-19 had increased risk of total ASQ scores below cutoff (exposed: 16.0% vs. unexposed: 6.1%; aOR, 3.57; 95% CI, 1.14-11.24). Conclusions: Antenatal maternal SARS-CoV-2 infection was not associated with overall impaired four-month infant neurodevelopmental screening. In exploratory analyses, severe maternal COVID-19 was associated with abnormal screening results.http://www.sciencedirect.com/science/article/pii/S1201971225001973Child developmentNeurodevelopmental disordersSARS-CoV-2InfantPregnancy complications, InfectiousPrenatal exposure delayed effects |
| spellingShingle | Johan Berg Karolina Linden Mehreen Zaigham Magnus Domellöf Fredrik Ahlsson Anders Elfvin Ulrika Åden Thomas Abrahamsson Andreas Ohlin Johannna Berg Linda Hjertberg Sofie Graner Sophia Brismar Wendel Linda Iorizzo Sofie Arnkil Ylva Carlsson Malin Veje Lina Bergman Verena Sengpiel Ola Andersson The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study International Journal of Infectious Diseases Child development Neurodevelopmental disorders SARS-CoV-2 Infant Pregnancy complications, Infectious Prenatal exposure delayed effects |
| title | The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study |
| title_full | The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study |
| title_fullStr | The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study |
| title_full_unstemmed | The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study |
| title_short | The association between antenatal SARS-CoV-2 exposure and infant neurodevelopment at four months of age: A prospective multicenter cohort survey within the COPE study |
| title_sort | association between antenatal sars cov 2 exposure and infant neurodevelopment at four months of age a prospective multicenter cohort survey within the cope study |
| topic | Child development Neurodevelopmental disorders SARS-CoV-2 Infant Pregnancy complications, Infectious Prenatal exposure delayed effects |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001973 |
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