Zolpidem Action During Prolonged Disorders of Consciousness (Case Report)
The paper describes two patients with prolonged disorders of consciousness (PDC) because of non-traumatic brain injury, in whom a clear neurodynamic response to Zolpidem was observed.In order to illustrate systemic cerebral responses to administration of this drug in LIC patients, an analysis of cli...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-11-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1817 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839578378284302336 |
|---|---|
| author | E. A. Kondratyeva M. V. Sinkin E. V. Sharova S. Laureys A. N. Kondratyev |
| author_facet | E. A. Kondratyeva M. V. Sinkin E. V. Sharova S. Laureys A. N. Kondratyev |
| author_sort | E. A. Kondratyeva |
| collection | DOAJ |
| description | The paper describes two patients with prolonged disorders of consciousness (PDC) because of non-traumatic brain injury, in whom a clear neurodynamic response to Zolpidem was observed.In order to illustrate systemic cerebral responses to administration of this drug in LIC patients, an analysis of clinical and electrophysiological changes has been undertaken.It has been shown that the result of Zolpidem applications in patients with prolonged disorders of consciousness (PDC) should be assessed not only by consciousness dynamics, but with the help of electroencephalogram (EEG) monitoring, too. Distinct response to Zolpidem during different periods of recovery in one patients was found.Zolpidem can render various effects in patients in vegetative state/with unresponsive wakefulness syndrome (VS/UWS) and in minimally conscious state (MCS). In one patient, sedation with EEG activation was observed, which was a sign of favorable prognosis. The other patient developed more than once local convulsions after Zolpidem administration followed by contact augmentation on the next day.The mechanism of action, necessary doses of drugs, and markers of forecasting the successful effect of that drug are yet to be further studied. |
| format | Article |
| id | doaj-art-9c7a36a19d0b4294816aa0b3e5f64ce2 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-9c7a36a19d0b4294816aa0b3e5f64ce22025-08-04T10:40:44ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-11-01155446010.15360/1813-9779-2019-5-44-601707Zolpidem Action During Prolonged Disorders of Consciousness (Case Report)E. A. Kondratyeva0M. V. Sinkin1E. V. Sharova2S. Laureys3A. N. Kondratyev4Polenov Neurosurgical Research Institute, branch of the Almazov National Medical Research CentreN. V. Sklifosovsky Research Institute of Emergency MedicineInstitute of Higher Nervous Activity and Neurophysiology of RASComa Science Group, GIGA-Consciousness, University and University Hospital of Liège, Domaine Universitaire du Sart TilmanPolenov Neurosurgical Research Institute, branch of the Almazov National Medical Research CentreThe paper describes two patients with prolonged disorders of consciousness (PDC) because of non-traumatic brain injury, in whom a clear neurodynamic response to Zolpidem was observed.In order to illustrate systemic cerebral responses to administration of this drug in LIC patients, an analysis of clinical and electrophysiological changes has been undertaken.It has been shown that the result of Zolpidem applications in patients with prolonged disorders of consciousness (PDC) should be assessed not only by consciousness dynamics, but with the help of electroencephalogram (EEG) monitoring, too. Distinct response to Zolpidem during different periods of recovery in one patients was found.Zolpidem can render various effects in patients in vegetative state/with unresponsive wakefulness syndrome (VS/UWS) and in minimally conscious state (MCS). In one patient, sedation with EEG activation was observed, which was a sign of favorable prognosis. The other patient developed more than once local convulsions after Zolpidem administration followed by contact augmentation on the next day.The mechanism of action, necessary doses of drugs, and markers of forecasting the successful effect of that drug are yet to be further studied.https://www.reanimatology.com/rmt/article/view/1817prolonged disorders of consciousnessminimally conscious stateunresponsive wakefulness syndromezolpidemconsciousness recovery prognosisvegetative state |
| spellingShingle | E. A. Kondratyeva M. V. Sinkin E. V. Sharova S. Laureys A. N. Kondratyev Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) Общая реаниматология prolonged disorders of consciousness minimally conscious state unresponsive wakefulness syndrome zolpidem consciousness recovery prognosis vegetative state |
| title | Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) |
| title_full | Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) |
| title_fullStr | Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) |
| title_full_unstemmed | Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) |
| title_short | Zolpidem Action During Prolonged Disorders of Consciousness (Case Report) |
| title_sort | zolpidem action during prolonged disorders of consciousness case report |
| topic | prolonged disorders of consciousness minimally conscious state unresponsive wakefulness syndrome zolpidem consciousness recovery prognosis vegetative state |
| url | https://www.reanimatology.com/rmt/article/view/1817 |
| work_keys_str_mv | AT eakondratyeva zolpidemactionduringprolongeddisordersofconsciousnesscasereport AT mvsinkin zolpidemactionduringprolongeddisordersofconsciousnesscasereport AT evsharova zolpidemactionduringprolongeddisordersofconsciousnesscasereport AT slaureys zolpidemactionduringprolongeddisordersofconsciousnesscasereport AT ankondratyev zolpidemactionduringprolongeddisordersofconsciousnesscasereport |