Dermatologic toxicity of high doses of tiothepa in children. Case report

Dermatologic toxicity of high doses of tiothepa in children. Case report

Hematopoietic stem cell transplantation (HSCT) is a treatment modality for a number of severe malignant and non-neoplastic diseases. Autologous hematopoietic stem cell transplantation (auto-HSCT) improves outcomes in patients with solid and hematological malignancies. Skin lesions at the auto-HSCT s...

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Bibliographic Details
Main Authors: Teimur Z. Aliev, Tatiana I. Potemkina, Tatiana S. Belysheva, Timur T. Valiev, Karina A. Sergeenko, Irina A. Kostareva, Lana M. Kudaeva, Elena B. Machneva, Tatiana L. Ushakova, Vladimir G. Polyakov, Kirill I. Kirgizov, Svetlana R. Varfolomeeva
Format: Article
Language:Russian
Published: Union of pediatricians of Russia 2023-05-01
Series:Педиатрическая фармакология
Subjects:
autologous hematopoietic stem cell transplantation
dermatologic toxicity
skin
tiothepa
high-dose chemotherapy
Online Access:https://www.pedpharma.ru/jour/article/view/2284
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Summary:Hematopoietic stem cell transplantation (HSCT) is a treatment modality for a number of severe malignant and non-neoplastic diseases. Autologous hematopoietic stem cell transplantation (auto-HSCT) improves outcomes in patients with solid and hematological malignancies. Skin lesions at the auto-HSCT stage are quite common and represent an important diagnostic and therapeutic problem. The most significant causes of skin lesions in auto-HSCT are drug toxicity, infectious and viral lesions. Each of the complications can manifest itself to varying degrees as well as combine with others, having a significant negative on the patient’s condition, posing a threat to the patient’s life in severe cases.
ISSN:1727-5776
2500-3089

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