Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis

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Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis

Tobacco smoking and alcohol consumption are significant risk factors for esophageal squamous cell carcinoma (ESCC), with their Collaborative interaction amplifying carcinogenic risks. To elucidate the role and underlying mechanisms of tobacco-alcohol co-exposure in ESCC pathogenesis, we treated the...

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Bibliographic Details
Main Authors:	Jianfeng Yuan, Jianxin Guo, Yu Wang, Tiantian Xing, Shuang Hou, Chenchen Zhang, Ming Huang, Pengfei Zheng, Ruifeng Li, Zhongbing Wu, Jing Li
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Biochemistry and Biophysics Reports
Subjects:	Esophageal squamous cell carcinoma Tobacco smoking 4-Nitroquinoline-1-oxide Ethanol TNF-α/TRAF2/NF-κB signaling pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580825002742
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