THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT)
Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related death in women worldwide. Currently, mammography and ultrasound are the methods most commonly used for the detection of BC, but these methods have significant limitations in the absence of “classic” vis...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2019-09-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1146 |
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| author | M. V. Pavlov S. A. Pegov A. G. Orlova G. Yu. Golubyatnikov L. V. Shkalova P. A. Malinina P. I. Rykhtik I. V. Turchin A. V. Maslennikova |
| author_facet | M. V. Pavlov S. A. Pegov A. G. Orlova G. Yu. Golubyatnikov L. V. Shkalova P. A. Malinina P. I. Rykhtik I. V. Turchin A. V. Maslennikova |
| author_sort | M. V. Pavlov |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related death in women worldwide. Currently, mammography and ultrasound are the methods most commonly used for the detection of BC, but these methods have significant limitations in the absence of “classic” visual symptoms of cancer in the breast tissue. In the complicated clinical situations, such methods as magnetic resonance imaging and positron emission tomography are used for the differential diagnosis of breast cancer. Over the past 20 years, the BC imaging capabilities have expanded due to the introduction of optical methods into clinical practice. These methods are based on differences in the optical properties between normal and pathological breast tissues. Optical imaging provides the ability to obtain indirect information about oxygenation, blood supply, delivery and consumption of oxygen in the breast tissue, as well as changes in its scattering properties. We present a clinical case of a woman with enlarged axillary lymph nodes. After the core biopsy of the lymph node, histological examination reveled breast cancer metastasis. The standard imaging modalities, such as digital mammography and ultrasound, did not show the evidence of breast cancer. However, the use of diffuse optical spectroscopy (DOS) allowed the detection of changes in the absorption and scattering coefficients in a small part of the breast tissue characteristic of a malignant tumor. Ultrasound and mammography images of this site of the breast demonstrated the features of benign lesion. After ultrasound-guided biopsy, cytological examination revealed cancer cells. Thus, the method of DOS allowed identification of changes characteristic to malignant tumor that was not detected by routine imaging modalities. |
| format | Article |
| id | doaj-art-9c20a797c80e48d3924e1eaf7ae64b7d |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-9c20a797c80e48d3924e1eaf7ae64b7d2025-08-04T10:33:39ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-09-011849210110.21294/1814-4861-2019-18-4-92-101662THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT)M. V. Pavlov0S. A. Pegov1A. G. Orlova2G. Yu. Golubyatnikov3L. V. Shkalova4P. A. Malinina5P. I. Rykhtik6I. V. Turchin7A. V. Maslennikova8Volga Region Medical Center,LLC «Center of Radiology» Tonus Premium»Institute of Applied Physics RASInstitute of Applied Physics RASVolga Region Medical CenterPrivolzhsky Research Medical UniversityVolga Region Medical CenterInstitute of Applied Physics RASPrivolzhsky Research Medical UniversityBreast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related death in women worldwide. Currently, mammography and ultrasound are the methods most commonly used for the detection of BC, but these methods have significant limitations in the absence of “classic” visual symptoms of cancer in the breast tissue. In the complicated clinical situations, such methods as magnetic resonance imaging and positron emission tomography are used for the differential diagnosis of breast cancer. Over the past 20 years, the BC imaging capabilities have expanded due to the introduction of optical methods into clinical practice. These methods are based on differences in the optical properties between normal and pathological breast tissues. Optical imaging provides the ability to obtain indirect information about oxygenation, blood supply, delivery and consumption of oxygen in the breast tissue, as well as changes in its scattering properties. We present a clinical case of a woman with enlarged axillary lymph nodes. After the core biopsy of the lymph node, histological examination reveled breast cancer metastasis. The standard imaging modalities, such as digital mammography and ultrasound, did not show the evidence of breast cancer. However, the use of diffuse optical spectroscopy (DOS) allowed the detection of changes in the absorption and scattering coefficients in a small part of the breast tissue characteristic of a malignant tumor. Ultrasound and mammography images of this site of the breast demonstrated the features of benign lesion. After ultrasound-guided biopsy, cytological examination revealed cancer cells. Thus, the method of DOS allowed identification of changes characteristic to malignant tumor that was not detected by routine imaging modalities.https://www.siboncoj.ru/jour/article/view/1146breast cancerearly detectionultrasound investigationx-ray mammographyoptical methods of diagnosticsdiffuse optical spectroscopytumor oxygen statusoptical properties of the tumor |
| spellingShingle | M. V. Pavlov S. A. Pegov A. G. Orlova G. Yu. Golubyatnikov L. V. Shkalova P. A. Malinina P. I. Rykhtik I. V. Turchin A. V. Maslennikova THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) Сибирский онкологический журнал breast cancer early detection ultrasound investigation x-ray mammography optical methods of diagnostics diffuse optical spectroscopy tumor oxygen status optical properties of the tumor |
| title | THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) |
| title_full | THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) |
| title_fullStr | THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) |
| title_full_unstemmed | THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) |
| title_short | THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT) |
| title_sort | role of diffuse optical spectroscopy in the diagnosis of breast cancer case report |
| topic | breast cancer early detection ultrasound investigation x-ray mammography optical methods of diagnostics diffuse optical spectroscopy tumor oxygen status optical properties of the tumor |
| url | https://www.siboncoj.ru/jour/article/view/1146 |
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