DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS

DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS

The new gel-sublimation technique for preparation porus biodegradable scaffolds (hydroxybutyrate-co-hydro- xyvalerate) is presented. The scaffolds with multi-mode internal structure have the of porus sizes varied from ~100 microns up to ~100 nanometers and the porosity in a range of 80–90%. A few te...

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Bibliographic Details
Main Authors: V. N. Vasilets, L. M. Zaitov, A. Y. Milentev, S. L. Nedoseev, P. V. Shvartskopf, V. A. Egorova, V. I. Sevastjanov
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2010-06-01
Series:Вестник трансплантологии и искусственных органов
Subjects:
cell technologies
biodegradable scaffolds
poly(hydroxybutyrate-co-hydroxyvalerate)
gel- sublimation technique
gas discharge plasma
hemolysis
cytotoxicity
Online Access:https://journal.transpl.ru/vtio/article/view/309
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Summary:The new gel-sublimation technique for preparation porus biodegradable scaffolds (hydroxybutyrate-co-hydro- xyvalerate) is presented. The scaffolds with multi-mode internal structure have the of porus sizes varied from ~100 microns up to ~100 nanometers and the porosity in a range of 80–90%. A few techniques for modification of 3D scaffolds by gas discharge plasma are developed and optimized: the microsecond dielectric barrier dischar- ge, the semi-self-maintained discharge supported by an electron beam; the nanosecond dielectric barrier dischar- ge. Biological tests including red blood cell hemolysis and cytotoxicity analysis have shown the possibilities of scaffolds applications for cell-based technologies.
ISSN:1995-1191

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