Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience
Introduction. Although uncommon from a population-based perspective, there is considerable morbidity and mortality associated with malignant tumors of the nose and paranasal sinuses.The objective of this study was to characterize the presentation, risk factors, management and survival of patients wi...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-11-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/669 |
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| author | L. G. Castelhano F. A. Correia D. F. Raposo A. H. Campos M. R. Melo S. A. Pereira M. C. Mariano L. Ferreira P. Montalvão M. T. Magalhães |
| author_facet | L. G. Castelhano F. A. Correia D. F. Raposo A. H. Campos M. R. Melo S. A. Pereira M. C. Mariano L. Ferreira P. Montalvão M. T. Magalhães |
| author_sort | L. G. Castelhano |
| collection | DOAJ |
| description | Introduction. Although uncommon from a population-based perspective, there is considerable morbidity and mortality associated with malignant tumors of the nose and paranasal sinuses.The objective of this study was to characterize the presentation, risk factors, management and survival of patients with these tumors treated at a single institution.Materials and methods. We retrospectively reviewed the clinical records of patients with malignancies of the nose and paranasal sinuses diagnosed between January 2010 and December 2014 at a tertiary cancer center. Univariate and multivariate analysis were performed.Results. Ninety patients were included in the study. Mean age at diagnosis was 62.8 years (range, 2–95 years) and mean follow-up was 44.5 months (range, 2–113 months). The maxillary sinus (33.3 %) and the nasal cavity (32.2 %) were the most frequent sites of origin. Squamous cell carcinoma (36.7 %), mucosal melanoma (15.6 %) and adenoid cystic carcinoma (10 %) were the most common histologic subtypes. Surgery was the primary treatment for 86.7 % of patients. Recurrence occurred in 45 patients (50 %). The overall 5‑year survival was 39.3 % and disease free-survival was 45.9 %. Survival was significantly decreased in non-smokers (p = 0.022), T3–4 tumors (p = 0.007), positive lymph nodes (p <0.001), nonepithelial tumors (p = 0.036) and positive margins (p = 0.032). Survival was not affected by surgical approach between endoscopic, open and combined approaches (p = 0.088).Conclusion. Prognosis is poor, with high recurrences and low survival, but clearly histology, location and stage-dependent. Sound oncologic principles, with complete resections and negative margins, result in a better outcome. |
| format | Article |
| id | doaj-art-9b2ac7e1c0bf4a75a2f1fcc5593c645c |
| institution | Matheson Library |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2021-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-9b2ac7e1c0bf4a75a2f1fcc5593c645c2025-08-04T14:05:33ZrusABV-pressОпухоли головы и шеи2222-14682411-46342021-11-01113101710.17650/2222-1468-2021-11-3-10-17451Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experienceL. G. Castelhano0F. A. Correia1D. F. Raposo2A. H. Campos3M. R. Melo4S. A. Pereira5M. C. Mariano6L. Ferreira7P. Montalvão8M. T. Magalhães9Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental RHospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental RHospital Prof. Doutor Fernando FonsecaHospital CUF TejoHospital Prof. Doutor Fernando FonsecaHospital de São José, Centro Hospitalar Universitário de Lisboa CentralHospital de São José, Centro Hospitalar Universitário de Lisboa CentralInstituto Português de Oncologia Francisco GentilInstituto Português de Oncologia Francisco GentilInstituto Português de Oncologia Francisco GentilIntroduction. Although uncommon from a population-based perspective, there is considerable morbidity and mortality associated with malignant tumors of the nose and paranasal sinuses.The objective of this study was to characterize the presentation, risk factors, management and survival of patients with these tumors treated at a single institution.Materials and methods. We retrospectively reviewed the clinical records of patients with malignancies of the nose and paranasal sinuses diagnosed between January 2010 and December 2014 at a tertiary cancer center. Univariate and multivariate analysis were performed.Results. Ninety patients were included in the study. Mean age at diagnosis was 62.8 years (range, 2–95 years) and mean follow-up was 44.5 months (range, 2–113 months). The maxillary sinus (33.3 %) and the nasal cavity (32.2 %) were the most frequent sites of origin. Squamous cell carcinoma (36.7 %), mucosal melanoma (15.6 %) and adenoid cystic carcinoma (10 %) were the most common histologic subtypes. Surgery was the primary treatment for 86.7 % of patients. Recurrence occurred in 45 patients (50 %). The overall 5‑year survival was 39.3 % and disease free-survival was 45.9 %. Survival was significantly decreased in non-smokers (p = 0.022), T3–4 tumors (p = 0.007), positive lymph nodes (p <0.001), nonepithelial tumors (p = 0.036) and positive margins (p = 0.032). Survival was not affected by surgical approach between endoscopic, open and combined approaches (p = 0.088).Conclusion. Prognosis is poor, with high recurrences and low survival, but clearly histology, location and stage-dependent. Sound oncologic principles, with complete resections and negative margins, result in a better outcome.https://ogsh.abvpress.ru/jour/article/view/669paranasal sinusessquamous cell carcinoma of head and neckmalignant melanomaendoscopic surgical procedures |
| spellingShingle | L. G. Castelhano F. A. Correia D. F. Raposo A. H. Campos M. R. Melo S. A. Pereira M. C. Mariano L. Ferreira P. Montalvão M. T. Magalhães Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience Опухоли головы и шеи paranasal sinuses squamous cell carcinoma of head and neck malignant melanoma endoscopic surgical procedures |
| title | Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience |
| title_full | Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience |
| title_fullStr | Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience |
| title_full_unstemmed | Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience |
| title_short | Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience |
| title_sort | malignant tumors of the nose and paranasal sinuses a retrospective review of a portuguese cancer center s experience |
| topic | paranasal sinuses squamous cell carcinoma of head and neck malignant melanoma endoscopic surgical procedures |
| url | https://ogsh.abvpress.ru/jour/article/view/669 |
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