ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE
Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a sel...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2020-09-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1540 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839579511838998528 |
|---|---|
| author | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva |
| author_facet | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva |
| author_sort | D. B. Erdyneeva |
| collection | DOAJ |
| description | Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. However, tamoxifen resistance is the major limitation of its efficacy. In this regard, the study of drug resistance mechanisms as well as search for biological prognostic markers of tamoxifen efficacy is very important. Cyclin D1 is a representative of the regulatory protein family, which plays a central role in the cell cycle regulation. The data on the association between cyclin D1 and estrogen-dependent signaling as well as the characteristics of CCND1 gene and its most studied polymorphic loci, were presented. The prognostic significance of cyclin D1 in hormone-receptor positive BC receptor-positive breast cancer was described. The experimental and clinical studies data on the association between the cyclin D1 expression level and tamoxifen efficacy are analyzed. Current approaches to overcoming hormone resistance based on cyclin D1 studies were considered. |
| format | Article |
| id | doaj-art-9b0a62a156e847f2895d31c20ae96a1d |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-9b0a62a156e847f2895d31c20ae96a1d2025-08-04T10:33:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682020-09-0119413814510.21294/1814-4861-2020-19-4-138-145777ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCED. B. Erdyneeva0N. N. Babyshkina1T. A. Dronova2S. V. Vtorushin3E. M. Slonimskaya4V. N. Stegniy5N. V. Cherdyntseva6Siberian State Medical UniversityCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State UniversityCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State UniversitySiberian State Medical University; Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesSt. Petersburg UniversityNational Research Tomsk State UniversitySiberian State Medical University; Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State UniversityHormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. However, tamoxifen resistance is the major limitation of its efficacy. In this regard, the study of drug resistance mechanisms as well as search for biological prognostic markers of tamoxifen efficacy is very important. Cyclin D1 is a representative of the regulatory protein family, which plays a central role in the cell cycle regulation. The data on the association between cyclin D1 and estrogen-dependent signaling as well as the characteristics of CCND1 gene and its most studied polymorphic loci, were presented. The prognostic significance of cyclin D1 in hormone-receptor positive BC receptor-positive breast cancer was described. The experimental and clinical studies data on the association between the cyclin D1 expression level and tamoxifen efficacy are analyzed. Current approaches to overcoming hormone resistance based on cyclin D1 studies were considered.https://www.siboncoj.ru/jour/article/view/1540hormone-receptor positive breast cancercyclin d1tamoxifenresistance mechanisms |
| spellingShingle | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE Сибирский онкологический журнал hormone-receptor positive breast cancer cyclin d1 tamoxifen resistance mechanisms |
| title | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_full | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_fullStr | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_full_unstemmed | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_short | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_sort | role of cyclin d1 in the mechanisms of tamoxifen resistance |
| topic | hormone-receptor positive breast cancer cyclin d1 tamoxifen resistance mechanisms |
| url | https://www.siboncoj.ru/jour/article/view/1540 |
| work_keys_str_mv | AT dberdyneeva roleofcyclind1inthemechanismsoftamoxifenresistance AT nnbabyshkina roleofcyclind1inthemechanismsoftamoxifenresistance AT tadronova roleofcyclind1inthemechanismsoftamoxifenresistance AT svvtorushin roleofcyclind1inthemechanismsoftamoxifenresistance AT emslonimskaya roleofcyclind1inthemechanismsoftamoxifenresistance AT vnstegniy roleofcyclind1inthemechanismsoftamoxifenresistance AT nvcherdyntseva roleofcyclind1inthemechanismsoftamoxifenresistance |