Features of lyophilization of a nanoliposomal drug
The conditions of lyophilization of nanoliposomes with encapsulated gentamicin (liposomal gentamicin) were studied. A mode of its safe lyophilization was suggested. A program for eliminating adverse factors was developed. It includes smooth increase of temperature from -70°C (freezing temperature) t...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2016-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/52 |
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| author | V. G. Pushkar K. A. Rotov I. V. Novitskaya E. A. Snatenkov |
| author_facet | V. G. Pushkar K. A. Rotov I. V. Novitskaya E. A. Snatenkov |
| author_sort | V. G. Pushkar |
| collection | DOAJ |
| description | The conditions of lyophilization of nanoliposomes with encapsulated gentamicin (liposomal gentamicin) were studied. A mode of its safe lyophilization was suggested. A program for eliminating adverse factors was developed. It includes smooth increase of temperature from -70°C (freezing temperature) to room temperature (22±2)°C and gradual reduction of vacuum from 30 to 10 Pa without jumps and drops. The characteristics of the labile nanoliposomal drugs were not lost. The suggested program consisted of 10 steps allowing computer control to attain a slow and uniform increase in the temperature of the frozen product. The precise control of pressure in the chamber was provided by a system of automatic regulation of vacuum supplied with the equipment. After the rehydration the lyophilized preparations completely restored their original shape and properties. |
| format | Article |
| id | doaj-art-9a4a8c9bbfa04441b38f9f67cb76a0a6 |
| institution | Matheson Library |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2016-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-9a4a8c9bbfa04441b38f9f67cb76a0a62025-08-04T10:19:37ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752016-10-01115818610.32362/2410-6593-2016-11-5-81-8652Features of lyophilization of a nanoliposomal drugV. G. Pushkar0K. A. Rotov1I. V. Novitskaya2E. A. Snatenkov3Volgograd Research Anti-Plague Institute, Supervision Service for Consumer Rights Protection and People’s Welfare of the Russian FederationVolgograd Research Anti-Plague Institute, Supervision Service for Consumer Rights Protection and People’s Welfare of the Russian FederationVolgograd Research Anti-Plague Institute, Supervision Service for Consumer Rights Protection and People’s Welfare of the Russian FederationVolgograd Research Anti-Plague Institute, Supervision Service for Consumer Rights Protection and People’s Welfare of the Russian FederationThe conditions of lyophilization of nanoliposomes with encapsulated gentamicin (liposomal gentamicin) were studied. A mode of its safe lyophilization was suggested. A program for eliminating adverse factors was developed. It includes smooth increase of temperature from -70°C (freezing temperature) to room temperature (22±2)°C and gradual reduction of vacuum from 30 to 10 Pa without jumps and drops. The characteristics of the labile nanoliposomal drugs were not lost. The suggested program consisted of 10 steps allowing computer control to attain a slow and uniform increase in the temperature of the frozen product. The precise control of pressure in the chamber was provided by a system of automatic regulation of vacuum supplied with the equipment. After the rehydration the lyophilized preparations completely restored their original shape and properties.https://www.finechem-mirea.ru/jour/article/view/52drugslyophilizationnanoliposomescryoprotectantstemperaturevacuum regulation |
| spellingShingle | V. G. Pushkar K. A. Rotov I. V. Novitskaya E. A. Snatenkov Features of lyophilization of a nanoliposomal drug Тонкие химические технологии drugs lyophilization nanoliposomes cryoprotectants temperature vacuum regulation |
| title | Features of lyophilization of a nanoliposomal drug |
| title_full | Features of lyophilization of a nanoliposomal drug |
| title_fullStr | Features of lyophilization of a nanoliposomal drug |
| title_full_unstemmed | Features of lyophilization of a nanoliposomal drug |
| title_short | Features of lyophilization of a nanoliposomal drug |
| title_sort | features of lyophilization of a nanoliposomal drug |
| topic | drugs lyophilization nanoliposomes cryoprotectants temperature vacuum regulation |
| url | https://www.finechem-mirea.ru/jour/article/view/52 |
| work_keys_str_mv | AT vgpushkar featuresoflyophilizationofananoliposomaldrug AT karotov featuresoflyophilizationofananoliposomaldrug AT ivnovitskaya featuresoflyophilizationofananoliposomaldrug AT easnatenkov featuresoflyophilizationofananoliposomaldrug |