Features of lyophilization of a nanoliposomal drug
The conditions of lyophilization of nanoliposomes with encapsulated gentamicin (liposomal gentamicin) were studied. A mode of its safe lyophilization was suggested. A program for eliminating adverse factors was developed. It includes smooth increase of temperature from -70°C (freezing temperature) t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2016-10-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/52 |
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| Summary: | The conditions of lyophilization of nanoliposomes with encapsulated gentamicin (liposomal gentamicin) were studied. A mode of its safe lyophilization was suggested. A program for eliminating adverse factors was developed. It includes smooth increase of temperature from -70°C (freezing temperature) to room temperature (22±2)°C and gradual reduction of vacuum from 30 to 10 Pa without jumps and drops. The characteristics of the labile nanoliposomal drugs were not lost. The suggested program consisted of 10 steps allowing computer control to attain a slow and uniform increase in the temperature of the frozen product. The precise control of pressure in the chamber was provided by a system of automatic regulation of vacuum supplied with the equipment. After the rehydration the lyophilized preparations completely restored their original shape and properties. |
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| ISSN: | 2410-6593 2686-7575 |