Human-relevant doses of bisphenol a induce insulin resistance by downregulating Irs1 expression in skeletal muscle through estrogen receptor-α

Human-relevant doses of bisphenol a induce insulin resistance by downregulating Irs1 expression in skeletal muscle through estrogen receptor-α

Emerging evidence links bisphenol A (BPA) to insulin resistance, but the underlying mechanisms remain unclear. In this study, lactating mother mice and their male offspring post-weaning were exposed to bisphenol A (BPA) via drinking water at human-relevant (2.5 μg/L) and high human-relevant (25 μg/L...

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Bibliographic Details
Main Authors: Zhang-Hong Ke, Yue-Hong Li, Ai-Li Yu, Xue-Fen Cai, Yan-Ying Lin, Shun-He Lin, Chu-Chu Zheng, Chen-Xi Yu, Bei-Hong Zheng, Yan Sun
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Bisphenol A
Skeletal muscle
Insulin resistance
Insulin receptor substrate 1
Estrogen receptor-α
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011364
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