Oxidative Stress in Critical Conditions and its Correction
Severe postoperative complications and critical conditions caused by profuse hemorrhage, pulmonary thromboembolism, anaphylactic shock in response to drugs, as well as circulatory arrest, pyoseptic processes are accompanied by significant activation of free radical lipid oxidation along with progres...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2008-04-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/799 |
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| author | N. A. Osipova N. V. Edeleva R. I. Yakubovskaya Ye. R. Nemtsova V. I. Chissov |
| author_facet | N. A. Osipova N. V. Edeleva R. I. Yakubovskaya Ye. R. Nemtsova V. I. Chissov |
| author_sort | N. A. Osipova |
| collection | DOAJ |
| description | Severe postoperative complications and critical conditions caused by profuse hemorrhage, pulmonary thromboembolism, anaphylactic shock in response to drugs, as well as circulatory arrest, pyoseptic processes are accompanied by significant activation of free radical lipid oxidation along with progressive depletion of the antioxidative defense system, i. e. the development of oxidative stress underlying the development of acute multiple organ dysfunctions (MOD) of posthypoxic or toxemic genesis, and they require special treatment policy. The active antioxidants Ceruloplasmin and Laprot based on natural human protein antioxidants are the drugs of choice in correcting oxidative stress. Their use as part of traditional intensive care restores imbalance of oxidative-antioxidative processes in the body and significantly enhances the efficiency of therapy for critical conditions and it should be regarded as an essential pathogenetic component of complex intensive care. The developed tactics of effective antioxidant therapy promotes optimization of the course of a rehabilitative period in patients after prior critical conditions and reduces the need for invasive hardware methods of correcting endotoxemia and MOD, which determines its economic expediency in addition to therapeutic one. Key words: critical conditions, oxidative stress, the antioxidants Ceruloplasmin and Laprot. |
| format | Article |
| id | doaj-art-99afd0c41b7b4308b47eb0e6f6049da2 |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2008-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-99afd0c41b7b4308b47eb0e6f6049da22025-08-04T10:40:38ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102008-04-014210.15360/1813-9779-2008-2-98799Oxidative Stress in Critical Conditions and its CorrectionN. A. OsipovaN. V. EdelevaR. I. YakubovskayaYe. R. NemtsovaV. I. ChissovSevere postoperative complications and critical conditions caused by profuse hemorrhage, pulmonary thromboembolism, anaphylactic shock in response to drugs, as well as circulatory arrest, pyoseptic processes are accompanied by significant activation of free radical lipid oxidation along with progressive depletion of the antioxidative defense system, i. e. the development of oxidative stress underlying the development of acute multiple organ dysfunctions (MOD) of posthypoxic or toxemic genesis, and they require special treatment policy. The active antioxidants Ceruloplasmin and Laprot based on natural human protein antioxidants are the drugs of choice in correcting oxidative stress. Their use as part of traditional intensive care restores imbalance of oxidative-antioxidative processes in the body and significantly enhances the efficiency of therapy for critical conditions and it should be regarded as an essential pathogenetic component of complex intensive care. The developed tactics of effective antioxidant therapy promotes optimization of the course of a rehabilitative period in patients after prior critical conditions and reduces the need for invasive hardware methods of correcting endotoxemia and MOD, which determines its economic expediency in addition to therapeutic one. Key words: critical conditions, oxidative stress, the antioxidants Ceruloplasmin and Laprot.https://www.reanimatology.com/rmt/article/view/799 |
| spellingShingle | N. A. Osipova N. V. Edeleva R. I. Yakubovskaya Ye. R. Nemtsova V. I. Chissov Oxidative Stress in Critical Conditions and its Correction Общая реаниматология |
| title | Oxidative Stress in Critical Conditions and its Correction |
| title_full | Oxidative Stress in Critical Conditions and its Correction |
| title_fullStr | Oxidative Stress in Critical Conditions and its Correction |
| title_full_unstemmed | Oxidative Stress in Critical Conditions and its Correction |
| title_short | Oxidative Stress in Critical Conditions and its Correction |
| title_sort | oxidative stress in critical conditions and its correction |
| url | https://www.reanimatology.com/rmt/article/view/799 |
| work_keys_str_mv | AT naosipova oxidativestressincriticalconditionsanditscorrection AT nvedeleva oxidativestressincriticalconditionsanditscorrection AT riyakubovskaya oxidativestressincriticalconditionsanditscorrection AT yernemtsova oxidativestressincriticalconditionsanditscorrection AT vichissov oxidativestressincriticalconditionsanditscorrection |