INFLUENCE OF THE COMPOUND SS-68 ON THE ELECTROPHYSIOLOGICAL EFFECTS OF ADRENOMIMETICS IN RAT RIGHT ATRIUM
The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenoreceptors by methoxamine (3×10-5М) led to prominent prol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2017-06-01
|
| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenoreceptors by methoxamine (3×10-5М) led to prominent prolongation of action potentials without significant changes in their rhythm. SS-68 attenuated this effect with IC50 = 5,27×10-6М. The standard α1-blocker prazosine appeared to be more effective (IC50 = 2×10-7М). The activation of β-adrenoreceptors by isoproterenol (3×10-7М) led to drastic acceleration of sinus rhythm. However, only the highest tested concentration of SS-68 (3×10-5М) reduced this effect, while the conventional β-blocker atenolol effectively inhibited it with IC50 = 3,95×10-6М. |
|---|---|
| ISSN: | 1608-6228 2541-9544 |