Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K/AKT pathway

Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K/AKT pathway

BackgroundHigh-altitude pulmonary edema (HAPE), a severe manifestation of hypoxia-induced pulmonary hypertension, continues to present a major health concern in high-altitude environments due to the absence of efficient preventive measures. This investigation explores the protective influence of gin...

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Bibliographic Details
Main Authors: Yacong He, Yilang Wang, Huxinyue Duan, Demei Huang, Nan Jia, Zherui Shen, Zhenxing Wang, Mingjie Wang, Tianzhu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
high-altitude pulmonary edema (HAPE)
ginsenoside Rg3 (G-Rg3)
PI3K/Akt pathway
ferroptosis
hypoxic pulmonary hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1644436/full
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