Characterization of free light chain impurity in a bispecific antibody

Characterization of free light chain impurity in a bispecific antibody

Bispecific antibodies (bsAbs) target two distinct binding sites, which enable novel mechanisms of action for the treatment of disease. Due to this structural complexity, bsAbs exhibit greater heterogeneity as compared to monospecific antibodies and may require nonstandard purification strategies to...

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Bibliographic Details
Main Authors: Monica Sadek, Neelima Mantha, Steffen Lippold, Delia Li, Kyle Spitler, Ran Li, Phillip Spinosa, Bob Liu, Steven Luu, Nicholas Woon, Yeying Zhang, Jia Guo, Renee Yang, Jonathan Zarzar, Yi Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Free light chain
oligomer
product-related impurities
biotherapeutics
stability
safety
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2527689
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