Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia
Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1547965/full |
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| author | Jinhuan Yue Jinhuan Yue Peng Wang Xiang-fa Guo Zeyi Wei Kaiting He Nuo Li Xiaoling Li Qinhong Zhang Qinhong Zhang Xiaoqing Zhou |
| author_facet | Jinhuan Yue Jinhuan Yue Peng Wang Xiang-fa Guo Zeyi Wei Kaiting He Nuo Li Xiaoling Li Qinhong Zhang Qinhong Zhang Xiaoqing Zhou |
| author_sort | Jinhuan Yue |
| collection | DOAJ |
| description | Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies. |
| format | Article |
| id | doaj-art-96e54d36b4a2407c95e513c7c06e5d8f |
| institution | Matheson Library |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-96e54d36b4a2407c95e513c7c06e5d8f2025-07-04T05:17:37ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-07-011710.3389/fnagi.2025.15479651547965Perspectives on resting-state functional magnetic resonance imaging research in vascular dementiaJinhuan Yue0Jinhuan Yue1Peng Wang2Xiang-fa Guo3Zeyi Wei4Kaiting He5Nuo Li6Xiaoling Li7Qinhong Zhang8Qinhong Zhang9Xiaoqing Zhou10Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, ChinaVitality University, Hayward, CA United StatesDivision of Oncology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Medical Imaging, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Medical Imaging, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Acupuncture, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, ChinaDivision of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaShenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Acupuncture, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, ChinaVascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1547965/fullvascular dementiaresting-state functional magnetic resonance imagingamplitude of low-frequency fluctuationsregional homogeneityfunctional connectivity |
| spellingShingle | Jinhuan Yue Jinhuan Yue Peng Wang Xiang-fa Guo Zeyi Wei Kaiting He Nuo Li Xiaoling Li Qinhong Zhang Qinhong Zhang Xiaoqing Zhou Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia Frontiers in Aging Neuroscience vascular dementia resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuations regional homogeneity functional connectivity |
| title | Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia |
| title_full | Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia |
| title_fullStr | Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia |
| title_full_unstemmed | Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia |
| title_short | Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia |
| title_sort | perspectives on resting state functional magnetic resonance imaging research in vascular dementia |
| topic | vascular dementia resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuations regional homogeneity functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1547965/full |
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