Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021
Background: The Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Disease (GBD) 2021 are two primary databases for assessing the global cancer burden. This study aimed to compare the incidence and mortality rates of tracheal, bronchus, and lung (TBL) cancer reported in these databas...
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Elsevier
2025-06-01
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| Series: | Journal of the National Cancer Center |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667005425000250 |
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| author | Zhifei Li Runze Li Jianchuan Chen Ruida Yang Peng Li Bin Qiu |
| author_facet | Zhifei Li Runze Li Jianchuan Chen Ruida Yang Peng Li Bin Qiu |
| author_sort | Zhifei Li |
| collection | DOAJ |
| description | Background: The Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Disease (GBD) 2021 are two primary databases for assessing the global cancer burden. This study aimed to compare the incidence and mortality rates of tracheal, bronchus, and lung (TBL) cancer reported in these databases and to analyze the observed discrepancies. Methods: Age-standardized rates (ASRs), including age-standardized incidence rates and age-standardized mortality rates for TBL cancer, were obtained from GLOBOCAN 2022 and GBD 2021 for the most recent available year. Differences in ASRs at the national level between the two databases were quantified using pairwise differences, calculated as the absolute difference in ASRs divided by the mean of the ASRs from both sources. Correlations between macroeconomic factors and pairwise differences in ASRs were evaluated, and country features correlated with high pairwise differences were assessed. The data sources and methods used in the two databases were also compared. Results: Strong correlations were identified between ASRs reported by GLOBOCAN 2022 and GBD 2021; however, significant differences were observed between estimates from the two data sources. African countries commonly exhibited larger pairwise differences in ASRs, whereas European countries demonstrated smaller pairwise differences in ASRs. Additionally, some populous developing countries, including China, South Africa, Brazil and India, showed smaller differences in ASRs. Countries lacking vital registration systems or high-quality population-based cancer registries displayed larger differences in ASRs. Furthermore, differences in ASRs were negatively correlated with macroeconomic factors. The data sources and estimation methods used by the two databases were inconsistent. Conclusions: Discrepancies in TBL cancer incidence and mortality were observed between GLOBOCAN 2022 and GBD 2021. While differences in sources and methods partially explain these discrepancies, a country's cancer surveillance maturity and economic status also correlate with the accuracy of the estimates. Estimating the cancer burden in less wealthy countries remains a substantial challenge, necessitating long-term assistance and investment. |
| format | Article |
| id | doaj-art-96df42f103484d7eb965a8ba03e2c7c8 |
| institution | Matheson Library |
| issn | 2667-0054 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the National Cancer Center |
| spelling | doaj-art-96df42f103484d7eb965a8ba03e2c7c82025-06-27T05:52:29ZengElsevierJournal of the National Cancer Center2667-00542025-06-0153267277Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021Zhifei Li0Runze Li1Jianchuan Chen2Ruida Yang3Peng Li4Bin Qiu5Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiothoracic Surgery, Zibo First Hospital, Shandong Second Medical University, Zibo, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding author.Background: The Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Disease (GBD) 2021 are two primary databases for assessing the global cancer burden. This study aimed to compare the incidence and mortality rates of tracheal, bronchus, and lung (TBL) cancer reported in these databases and to analyze the observed discrepancies. Methods: Age-standardized rates (ASRs), including age-standardized incidence rates and age-standardized mortality rates for TBL cancer, were obtained from GLOBOCAN 2022 and GBD 2021 for the most recent available year. Differences in ASRs at the national level between the two databases were quantified using pairwise differences, calculated as the absolute difference in ASRs divided by the mean of the ASRs from both sources. Correlations between macroeconomic factors and pairwise differences in ASRs were evaluated, and country features correlated with high pairwise differences were assessed. The data sources and methods used in the two databases were also compared. Results: Strong correlations were identified between ASRs reported by GLOBOCAN 2022 and GBD 2021; however, significant differences were observed between estimates from the two data sources. African countries commonly exhibited larger pairwise differences in ASRs, whereas European countries demonstrated smaller pairwise differences in ASRs. Additionally, some populous developing countries, including China, South Africa, Brazil and India, showed smaller differences in ASRs. Countries lacking vital registration systems or high-quality population-based cancer registries displayed larger differences in ASRs. Furthermore, differences in ASRs were negatively correlated with macroeconomic factors. The data sources and estimation methods used by the two databases were inconsistent. Conclusions: Discrepancies in TBL cancer incidence and mortality were observed between GLOBOCAN 2022 and GBD 2021. While differences in sources and methods partially explain these discrepancies, a country's cancer surveillance maturity and economic status also correlate with the accuracy of the estimates. Estimating the cancer burden in less wealthy countries remains a substantial challenge, necessitating long-term assistance and investment.http://www.sciencedirect.com/science/article/pii/S2667005425000250Global Cancer Observatory 2022Global Burden of Disease 2021IncidenceMortalityTracheal, bronchus, and lung cancer |
| spellingShingle | Zhifei Li Runze Li Jianchuan Chen Ruida Yang Peng Li Bin Qiu Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 Journal of the National Cancer Center Global Cancer Observatory 2022 Global Burden of Disease 2021 Incidence Mortality Tracheal, bronchus, and lung cancer |
| title | Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 |
| title_full | Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 |
| title_fullStr | Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 |
| title_full_unstemmed | Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 |
| title_short | Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 |
| title_sort | differences in the incidence and mortality of tracheal bronchus and lung cancer between the global cancer observatory 2022 and the global burden of disease 2021 |
| topic | Global Cancer Observatory 2022 Global Burden of Disease 2021 Incidence Mortality Tracheal, bronchus, and lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2667005425000250 |
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